Naked DNA Viruses with Icosahedral Symmetry

These families are non-enveloped, icosahedral DNA viruses:

1.Parvoviridae

2.Papillomaviridae

3.Polyomaviridae

4.Adenoviridae

Genome: Single-stranded DNA (ssDNA), linear

Parvoviridae

Parvoviridae Key Virus:

Parvovirus B19

Parvoviridae Associated Disease:

•Erythema infectiosum (Fifth disease)

•Aplastic crisis (in patients with hemolytic anemia)

•Hydrops fetalis (in fetuses)

•Polyarthritis (especially in adults)

First disease –

Measles (caused by measles virus)

Second disease –

Scarlet fever (caused by Streptococcus pyogenes)

Third disease –

Rubella (German measles, caused by rubella virus)

Fourth disease –

Dukes' disease (now largely obsolete or disputed)

Fifth disease –

Erythema infectiosum (caused by Parvovirus B19)

Sixth disease –

Roseola infantum (caused by Human herpesvirus 6 or 7)

Genome: Double-stranded DNA (dsDNA), circular

Papillomaviridae, Polyomaviridae

Papillomaviridae Key Virus:

Human papillomavirus (HPV)

Papillomaviridae Associated Disease:

• Cutaneous and anogenital warts (e.g., HPV 6 and 11)

• Cervical, anal, penile, vulvar, and oropharyngeal cancers (e.g., HPV 16 and 18)

Polyomaviridae Key Viruses:

JC virus (JCV)

BK virus (BKV)

Causes progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals.

JC virus (JCV):

Causes nephropathy and hemorrhagic cystitis, especially in transplant patients.

BK virus (BKV):

Adenoviridae Key Virus:

Human adenovirus

Adenoviridae Diseases:

•Upper respiratory tract infections (e.g., pharyngitis)

•Conjunctivitis (pink eye)

•Gastroenteritis (especially in children)

•Hemorrhagic cystitis

Adenoviridae serotypes identified

>80

Adenovirus prevention

Oral live vaccine used in U.S. military personnel

Serology Parvoviridae

IgM and IgG

Antiviral for Adenoviridae

Cidofovir

Genome: Double-stranded DNA (dsDNA), linear

Adenoviridae