💊 MISCELLANEOUS AGENTS FOR CONSTIPATION

What is the primary action of Lactulose?

Pulls water into the colon to soften stool and lowers blood ammonia levels.

What class of drug is Lubiprostone?

Chloride channel activator.

What condition is Lactulose NOT typically used for?

Direct treatment of opioid constipation.

What is the mechanism of action of Sorbitol?

Pulls water into the bowel via osmotic pressure.

Indicate the first-line use condition for Tegaserod?

Short-term treatment for IBS-C in women under 65.

What are the two main indications for Lactulose?

Constipation and hepatic encephalopathy.

What is a common adverse effect of Prucalopride?

Diarrhea and nausea.

Which medication is contraindicated in a female patient over 65 years old?

Tegaserod.

What is the dosage for Lubiprostone when treating CIC?

24 mcg PO BID with food.

What is an important monitoring consideration for patients on Lubiprostone?

Watch for nausea and severe diarrhea.

What is the dosing for Lactulose when treating hepatic encephalopathy?

20–30 g PO 3–4 times daily.

What are the potential serious risks associated with Tegaserod?

MI, angina, stroke, TIA.

What is the action of Prucalopride?

Stimulates normal GI peristalsis.

What should be monitored closely in patients taking Lubiprostone for dizziness and shortness of breath?

Blood pressure.

What is a known adverse effect of all hyperosmotic agents like Lactulose and Sorbitol?

Electrolyte imbalances.

Which medication can be used with Kayexalate for hyperkalemia?

Sorbitol.

What should be done if a patient experiences acute dyspnea after taking Lubiprostone?

Tell them to lie down and monitor BP.

What is the route of administration for Sorbitol?

Can be given orally or rectally.

What is a crucial point regarding the use of Prucalopride in relation to mental health?

Monitor for suicidal ideation and depression.

What is the common dosing for lactulose for constipation treatment?

10–20 g (15–30 mL) PO daily.