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Top down control of impulsivity
VMPFC inhibits ventral striatum
Top down control of conpulsive acts
Orbitofrontal cortex inhibits dorsal striatum
Impuslsivity
Ventral striatum
Compulsive
Dorsal striatum
DA mesolimbic reward pathway
VTA → nucleus accumbeans
What do all addictive drugs have in common
They all increase DA in nucleus accumbeans
Nicotine
Increases DA release in VTA
What helps with smoking cessation
NDRIs
What is cocaine mechanism
block DAT, NET and 5-HT
Amphetamines mechanism of action
block DAT
amphetamines short term effects
Euphoria
amphetamines long term effects
paranoid schizophrenia like symptom
What are CB1 and Cb2
metabotropic
Where is CB1/2 mostly located
GABA axons