Paget's Disease

Define Paget disease

osteometabolic disorder

focal disorder of accelerated skeletal remodeling that may affect one or more bones

What is another name for paget disease?

osteitis deformans

Describe the remodeling in Paget disease

produces a slowly progressive enlargement and deformity of multiple bones

How many phases are there in Paget disease?

3

Define phase I of Paget disease

osteolytic phase

prominent bone resorption and hypervascularization

Define phase of Paget disease

sclerotic phase

decreased cellular activity and vascularity

Define phase III of Paget disease

mixed phase

both active bone resorption and compensatory bone formation

Describe the bones in phase III of Paget disease

sponge like

weakened

deformed

What are the risk factors of Paget disease?

after osteoporosis

What are the complications of paget disease?

fractures

delayed union

progressive skeletal deformities

chronic bone pain

neurologic compromise of PNS and CNS (facial or ocular nerve compression)

spinal stenosis

pagetic arthritis

Bone pain associated with Paget’s disease is described as?

aching

deep

boring

worse at night

diminishing but not disappearing with physical activity

Involvement of the lumbar spine may produce symptoms of?

spinal stenosis

Involvement of cervical and thoracic spine may predispose patients to?

myelopathy

What is the cause of Paget’s disease?

insidious