1/102
Looks like no tags are added yet.
Name | Mastery | Learn | Test | Matching | Spaced |
---|
No study sessions yet.
Describe the process of spermatogenesis.
spermatogenesis occurs in the seminiferous tubules within the testes
outer layer = spermatogonium —> diploid cells
divides via mitosis to maintain numbers and then by meiosis to make sperm
cells near centre = begin meiosis
called primary spermatocytes
after the first division they are haploid and secondary spermatocytes
after the 2nd division they are called spermatids
sperm migrate to epididymus for final maturation
stay there for up to 1 month
testosterone causes them to make lots of mitochondria, create a tail and get rid of excess cytoplasm
Outline the main differences between spermatogenesis and oogenesis.
each primary spermatocyte undergoes 1st meiotic division to become 2 secondary spermatocytes (n)
each primary oocyte undergoes 1st meiotic division - one of the resulting cells becomes a secondary oocyte (n) and the other the first polar body
2nd secondary spermatocytes undergo 2nd meiotic division to form 4 spermatids (n)
secondary oocyte (n) commences the second meiotic division but stops at metaphase producing a second polar body (n) and an ootid (n). First polar body (n) may also undergo the 2nd meiotic division resulting in two polar bodies (n)
spermatids mature into sperm (n)
ootid matures into an ovum (n)
Describe the main events of the ovarian cycle.
oestrogen is high as it is repairing endometrium
leutinizing and follicle stimulating are increasing to allow for the maturation of follicles
follicles undergoes…
primary follicle enlarges and divides = layer of cells around oocyte
cells secrete fluid around oocyte and force it towards the side of the follicle —> now called secondary follicle
more fluid = moves to surface of ovary
near surface = bulges like blister (Graafian/mature follicle)
lots of secondary follicles are created during this process but are reabsorbed into ovary
DAY 14 = oestrogen levels cause a spike in LH and FSH —> ovulation where mature follicle expels oocyte and it travels down Fallopian tube
ruptured follicle collapses and blood clot forms but is absorbed by remaining follicle cells
forms cream coloured body called the corpus luteum
corpus luteum secretes progesterone mainly but also a bit of oestrogen
progesterone allows the uterine lining to thicken and develop for potential fertilisation
inhibits the release of FSH and LH = no more follicle development
if no fertilisation, corpus lutetium develops maximally 8-10 days after ovulation = degenerates into a fibrous mass of scar tissue the corpus albicans
progesterone and oestrogen decreases and menstruation occurs
fertilisation occurs
corpus luteum does no degenerate and continues to grow and is maintained by human chronic gonadotropin
HCG aids the developing placenta
once placenta can produce oestrogen and progesterone, corpus luteum degenerates
ovarian cycle resumes after childbirth
Describe the main events of the menstrual cycle.
series of changes to the uterus during the ovarian cycle
follicle is maturing
progesterone causes endometrium to thicken and become softer
after ovulation
endometrium contines to thicken
secretes watery mucus
if egg is not fertilised, corpus luteum degenerates reducing progesterone and breaks down
14 days after ovulation, blood from broken capillaries, mucus and cell debris is shed with the endometrium through vagina
the phases
menstrual
lining shed
vessels constrict reducing blood flow
proliferative
lining regenerates by oestrogen
number of blood vessels up
secretory
lining is maintained by progesterone and is ready for embryo implantation
glands release watery, glycogen rich mucus into uterine cavity
Describe the process of fertilisation and state where and when it occurs.
usually occurs in the Fallopian tubes after an egg has been ovulated
sexual intercourse occurs where the penis enters the vagina
ejaculation where semen enters the vagina
sperm: vagina - cervix - uterus - Fallopian tubes
in a few minutes
muscular contraction of uterus helps sperm travel there
fertilisation usually occurs when egg is 1/3 the way down the uterine tube
secondary oocyte = metaphase 2
outer: corona radiata = follicles held by cementing materials of oocyte
inner: corona pellucida = glycoprotein matrix surrounding plasma membrane of oocyte
acrosome of sperm has enzyme that breaks down cementing materials in corona radiata
many thousands needed for ONE sperm to penetrate the egg
sperm penetrates pellucida = acrosomal reaction where digestive enzymes are released
breaks down glycoprotein matrix = access to plasma membrane
plasma membranes of oocyte and spermatozoa fuse = sperm nucleus enters ovum
fertilisation causes membrane to form around ovum = no more sperm in oocyte
tail absorbed
2nd division is complete
1 nucleus = diploid
zygotę is created
Explain the following assisted reproductive technologies procedures – AID, IVF, GIFT, ICSI
ovulation induction
woman has ovulation problems, fertility drugs can be used
these drugs have LH and FSH
stimulate egg growth and ovulation
if ovulation induced successfully, conception may occur naturally
fertility drugs also used to produce multiple eggs for IVF procedures and improve endometrium's condition
Artificial Insemination
concentrated does of sperm from a woman's partner or donor is injected into the woman's uterus during ovulation
IVF = in vitro fertilisation
in vitro = in glass (outside of body)
in vivo = inside living body
IVF
eggs and sperm are combined in the lab to facilitate fertilisation
the resulting embryos can be transferred to the woman's uterus and undergo normal development or frozen for future use
Ovarian stimulation
fertility drugs stimulate ovaries to produce many eggs
progress of follicles is monitored using ultrasound
Egg retrieval
eggs harvested using transvaginal ultrasound aspiration
ultrasound is used to guide a fine needle through vagina wall and into ovary
mature eggs are sucked into hollow needle
insemination, fertilisation and embryo culture
best of the harvested eggs are either added to sperm in IVF future medium and fertilisation is allowed to take place, or the sperm may be injected directly into the egg
preimplantation genetic diagnosis
may be carried out to screen for specific inherited diseases before the embryo is transferred
common fertility treatments
GAMETE INTRAFALLOPIAN TRANSFER (GIFT)
if Fallopian tubes normal, sperm + egg introduced into tube and fertilisation occurs in own body
ZYGOTE INTRAFALLOPIAN TUBE TRANSFER (ZIFT)
fertilisation occurs in lab and zygote placed in Fallopian tube
INTRACYTOPLASMIC SPERM INJECTION (ICSI)
single healthy sperm injected into egg
zygotę introduced into f-tube or uterus
EPIDIDYMAL AND TESTICULAR SPERM EXTRACTION
man's sperm duct is blocked, sperm for ICSI procedure can be extracted directly from testes or sperm duct
Describe the events that take place from the formation of the zygote to the blastocyst stage when implantation occurs. (Include the timing of significant events).
zygote undergoes mitosis whilst travelling to uterus creating morula in the first 3-4 days after fertilisation
cell number up but not size
after 4-5 days cells rearrange forming blastocyst
hollow ball of 100 cells
cavity filled with fluid
inner cell mass of 30 cells
7 days after fertilisation = implantation
blastocyst embeds in endometrial lining
blastocyst gains nourishment by absorbing nutrients from glands and blood vessels in lining
lining is maintained by progesterone by corpus luteum until placenta is formed after 12 weeks
Summarise the significant events that occur during embryonic (week 0 – 8)
week 1
fertilisation
morula forms
blastocyst forms
sheds zona pellucida = membrane surrounding embryo before implantation
implantation begins
week 2
amniotic cavity and yolk sac appear
implantation complete
future placenta starts to develop
week 3
ectoderm, mesoderm, endoderm form
future backbone appears
blood and vascular system start to develop
week 4
embryo distinguishable
body segments and future skeleton visible
major organs start developing
week 5
recognisable
2.5-7mm long
cartilaginous skeleton begins to develop
limb buds developing
week 7
head rounded
eyes conspicuous
hands and feet
straightens
tail disapears
ossification
week 8
27-31 mm
face and limbs well developed
first movements
90% of adult structures established
gender can be determined
Describe the structure and function of the placenta.
structure
small finger like extensions called chorionic villi contains foetus blood vessels and extend into endometrium
surrounded by maternal blood pools from uterine arteries
large surface are for diffusion
substances diffuse between circulatory systems
umbilical cord attaches at one end of foetus and to placenta
2x arteries (blood to placenta
1x vein (blood to foetus)
function
supplies oxygen, nutrients and antibodies to foetus
carbon dioxide and waste removal from foetus
anchors foetus to uterus
releases hormones to maintain pregnancy (endocrine gland)
maternal health
linked with foetal health
once pregnant, woman should alter her lifestyle to meet new circumstances and accomodate the changes her body will undergo
ductus arteriosus and foramen ovale
blood returning to foetal heart enters right atrium and can follow several pathways
Lungs are collapsed and not functioning = considerable resistance to blood flow and little blood reaches lungs
most of blood from right ventricle flows through ductus arteriosus which allows blood from pulmonary artery to flow directly into the aorta
right atrium blood may flow directly to left by the opening called the foramen ovale
beneficial as blood from the placenta is highly oxygenated and can flow to the developing foetal tissues via aorta very fast
changes to circulation at birth
no longer dependent on placenta for food and oxygen
lungs and liver must become fully functional = blood must flow through them
important that ductus venous, ductus arterioles and foramen ovale close
first breath = stimulated by shock of birth or slap on bum
clamping the umbilical vessels = CO2 in baby's blood rises
as lungs expand = no longer resist blood flow = flow in ductus arteriosus down
all that is left of ductus arteriosus after a few weeks is a fibrous mass of tissue
pressure in left atrium increases = flap of foramen ovale closes permanently
bypass of liver closed = must go to liver
if fails to close = hole in heart
indication = bluish colour due to insufficient O2
surgery can be performed to close this and provide normal circulation
baby breathes about 45 breaths per minute for the first 2 weeks
gradually slows
125 - 130 beats per minute often going to 180 bpm when excited
more muscular activity and keeping baby warm in cooler environment
higher red blood cell count for extra O2 for tissues
WBC count is very high at birth but decreased rapidly by 7th day
genital herpes
causes
intercourse and oral sex
symptoms
Herpes Simplex 2 = strain related to (same word 1) which is responsible for cold sores
some people experience a single episode of herpes, others it is recurrent
some not only display symptoms but may be able to pass It on
painful blistering
active sores are usually source of infection
no long term health problems
treatment
bathe area with salt solution
pain medication
creams
once infected, virus remains in the body
although symptoms can be treated, there is no cure
in newborns
mothers infected in last trimester = risk infecting baby
40% of babies infected = die or have severe brain damage
c-section = generally performed if mother is suspected of having herpes
genital warts
causes
intercourse and oral sex
symtoms
caused by Human Papilloma Virus (HPV)
warts generally appear around external genitalia, can also be internal
responsible for 70% of cervical cancer cases in women
painless, but may be itch warts
blood in urine
blood in faeces
pain or bleeding during sex
treatment
external warts can be removed using laser
anti-wart ointment
never get rid of genital warts virus