Drug Card for Fentanyl

Fentanyl

A potent synthetic opioid analgesic used for pain management and anesthesia.

Sublimaze

A trade name for Fentanyl.

Duragesic

Another trade name for Fentanyl.

Opioid Analgesic

A classification for drugs that are used primarily for pain relief.

How does Fentanyl work in the body?

It binds to opioid receptors, primarily the mu receptor, to inhibit pain signaling.

Pharmacokinetics of Fentanyl - Absorption

Variable absorption; available in IV and transdermal forms.

Pharmacokinetics of Fentanyl - Distribution

Rapidly distributed with a high volume of distribution.

Where is Fentanyl metabolized?

In the liver by the CYP3A4 enzyme.

How is Fentanyl excreted from the body?

It is excreted through urine.

Indications for Fentanyl

Used for severe pain management and as an adjunct to anesthesia.

Contraindications for Fentanyl

Includes respiratory depression and opioid intolerance.

Common side effects of Fentanyl

Respiratory depression, nausea, and constipation.

Adult dosing for Fentanyl

50-100 mcg IV every 1-2 hours as needed.

Pediatric dosing for Fentanyl

Typically 1-2 mcg/kg based on weight.

Precautions when using Fentanyl

There is a risk of addiction and respiratory depression.

Drug-drug interactions with Fentanyl

Includes CNS depressants and MAO inhibitors.