Pharm Dermatology Medications

UVA exposure causes

premature aging

wrinkles

age spots

main cause of sunburn

UVB rays

which UV ray passes through window glass

UVA

broad-spectrum sunscreens containing _ are recommended

zinc oxide

titanium dioxide

SPF stands for

sun protection factor

steroid MOA - anti inflammatory effect

stabilizes the lysosomes in neutrophils

prevents degranulation

steroid MOA for immunosuppression

-inhibition of humoral factors involved in inflammatory response

-suppression of immune cells

topical steroids class 1

clobetasol proprionate

betamethasone diproprianate

topical steroids class 2

betamethasone

fluocinde

desoximetasone

triamcinalone acetonide

topical steroids class 3

triamcinalone acetonide

betamethasone valerate

topical steroids class 4

triamcinalone acetonide

hydrocortisone valerate

topical steroid class 5

desonide

hydrocortisone

topical steroid class 6

desonide

topical steroid class 7

0.5-1% hydrocortisone acetate

most potent vehicle for topical steroid

ointment

rank order of topical steroid vehicle potencies

ointment > creams > gels/lotions > foams

topical ointments should be used for what skin types

dry, thickened skin

topical creams should be used for what skin types

moist or weeping lesions

gels should be used for what skin types

flexural and hair-bearing areas

adverse reactions to topical steroids

tachyphylaxis

skin atrophy

telangectasias

striae

discoloration

HPA axis suppression

indications for topical steroids (9)

psoriasis

atopic contact

seborrheic dermatitis

nummular dermatitis

lichen planus

lupus

vitiligo

arthropod bites

alopecia areata

contraindications for topical steroids

infections

skin atrophy

allergic contact dermatitis

pregnancy

lactation

additive of topical steroids that causes irritation

propylene glycol

don't use strong topical steroids on what part of the body

skin folds

factors that contribute to rosacea (5)

inflammatory cytokines

vascular hypersensitivity

UV radiation

demodex mite

skin barrier dysfunction

rosacea topical treatments

metronidazole

sodium sulfacetamide

brimonidine tartrate

oxymetazoline cream

azelaic acid

mincocycline

ivermectin

oral rosacea treatment

doxycycline and minocycline

common adverse effects of tetracyclines

GI upset

photosensitivity

C. acnes resistance

tooth discoloration

vertigo

permethrin class

ectoparasticide

permethrin MOA

disrupts Na channel currents in the nerve cell membrane

delayed repolarization leads to paralysis and death of parasite

pyrethrins MOA

stimulate then block nerve impulses -> paralysis

pyrethrins are used for _

head/body/pubic lice

ectoparasiticide examples (5)

permethrin

pyrethrin

ivermectin

spinosad

malathion

treatment for scabies

permethrin 5% cream

ivermectin oral

treatment for lice

permethrin 1% and 5% cream

Natroba topical suspension

pyrethrin

treatment for resistant lice infection

ivermectin oral

hydroxyzine uses

pruritius from allergic condtions

histamine-mediated pruritis

hydroxyzine MOA

suppresses activity in key subcortical regions of CNS

valacyclovir and acyclovir indications

HSV and VZV infections

oral and genital herpes

reduction of HSV transmition

shingles

chickenpox

valacyclovir is what type of drug

prodrug - not active itself

OTC to shorten cold sore symptoms

docosanol 10% (Abreva)

MOA of docosanol

blocks fusion of the viral envelope with the cell membrane

prevents viral entry and replication

topical antifungal MOA

disrupt fungal cell membrane

topical antifungals that work for yeast

ketaconzazole

nystatin (mycostatin)

selenium sulfide

therapy of onychomycosis

terbinafine

itraconazole

fluconazole

topical wart agents

cantharidin

podofilox

salicylic acid

imiquiod

oral antifungals

fluconazole

terbinafine

itraconazole

griseofulvin

cantharidin MOA

induces a vesiculobullous dermatosis

treatment for genital warts

imiquimod

podofilox

podofilox MOA

induces necrosis by preventing cell mitosis

topical actinic keratosis treatment

5-FU

imiquimod

tirbanibulin

5-FU MOA

blocks thymidylate synthase -> halts DNA and RNA synthesis

imiquimod MOA

stimulates toll like receptor 7

releases interferon alpha and cytokines

tirbanibulin MOA

-microtubule inhibitor

-arrests cell division of rapidly proliferating atypical keratinocytes

-disrupts Src kinase signaling

topical retinoid of psoriasis

tazarotene

tazarotene MOA

regulates retinoid-responsive genes controlling cell proliferaiton, differntiation ,inflammation

vitamin D analogs for psoriasis

calcipotriene

calcitriol

vitamin D analogs MOA

act on vitamin D receptor

-less proliferation, more differentiation

topical calcineurin inhibitors

tacrolimus

pimecrolimus

MOA of topical calcineurin inhibitors

binds and inhibits calcineurin -> reduces proliferation of T lymphocytes

Vtama drug name and class

tapinarof ; aryl hydrocarbon agonist

Vtama/tapinarof MOA

suppresses Th17 cells

restores skin barrier proteins

induces Nrf2 pathway to boost antioxidant activity

Zoryve drug name, class

roflumilast; PDE4

inhibiting PDE4 leads to

increased level of intracellular cAMP

methotrexate MOA

antifolate (blocks DNA synthesis)

promotes adensoine accumulation

cyclosporine class

calcineurin inhibitor

labs for methotrexate

CBC

LFTs

renal function

cyclosporine binds _

cyclophilin

cyclosporine MOA

blocks NFAT-driven transcription of IL-2

suppresses T cell activation

main drug interaction with methotrexate

Bactrim

monitoring for cyclosporine

blood pressure and creatinine

apremilast brand name and class

Otezla; PDE4 inhibitor

avoid what drugs apremilast?

drugs that induce CYP450 system

deucravacitinib brand name and class

Sotyktu; TKY2 inhibitor

TYK2 MOA

disrupts important link between Il-23 and IL-17

TNF-a inhibitors

adalimumab (Humira)

etanercept (enbrel)

infliximab (remicade)

certolizumab (cimzia)

IL-12/23 inhibitor

ustekinumab (Stelara)

IL-23 inhibitors

Tremfya (guselkumab)

Skyrizi (risankizumab)

Ilumya (tildrakizumab)

IL-17 with a boxed warning

brodalumab

which drug class works best for psoriatic arthritis and psorasis combined

IL-17

who should receive systemic treatment for psoriasis

moderate to severe psoriasis

active psoriatic arthritis

safety consideration for TNF inhibitors

serious infection

TB

hepatitis

CHF

IL-17 inhibitor safety consideration

infection

candidiasis

neutropenia

worsening of Crohn's

topicals for atopic dermatitis

tacrolimus

pimecrolimus

roflumilast

crisaborole

crisaborole brand name and class

Eucrisa, topical PDE4 inhibitor

systemics for atopic dermatitis

IL-4 inhibitor

IL-13 inhibitor

IL-31 inhibitor

Dupixent age approval

6 months +

Dupixent MOA

blocks IL-4 and IL-13

Dupixent drug name

dupilumab

tralokinumab (Adbry) MOA

IL-13 blocks

biologics for atopic dermatitis

Ebglyss

Dupixent

Adbry

Nemluvio

Cibinqo MOA

JAK1 inhibtor

JAK inhibitors for atopic dermatitis

abrocitinib (Cibinqo)

upadacitinib (Rinvoq)

topical JAK inhibitor for atopic dermatitis

ruxolitinib (Opzelura)