innate immune system review

What type of receptor do macrophages use to detect pathogens

Pattern Recognition Receptors

what type of receptors to phagocytic cells use

• PRR

• Antibody receptors

• Activated complement receptors

What cells are the professional phagocytes

• neutrophils

• macrophages

• monocytes

• Dendritic cells

What are the sentinel cells

• macrophages

• mast cells

What do you see with an immune system activation

inflammation

Clinical signs of inflammation

PRISH

3 pathways of activation

classical, alternate, lectin

Classical pathway

Antibody dependant

Alternate pathway

Spontaneous activation of C3, but mammalian cells inactivate it

lectin pathway

PRRs for sugars in bacterial cell walls

First common step in the activation pathways

C3

Consequences of complement activation

• Opsonization (improved phagocytosis)

• direct destruction of pathogens (membrane attack complex)

• Promote inflammation (attract phagocytes, stimulates mast cell degranulation )

How does the neutrophil bind

• PRR for gram positive cell wall

• activated complement (mannan binding lectin alternate complement pathway)

how does the innate immune system remove virus in animals with no adaptive immunity

• NK lymphocytes

• Interferon production