M, Pharmaceutical Chemistry (without options)

Which of following are weak acids

A. HNO2; H2SO4; HCl

B. H2CO3; CH3COOH; HF

B. H2CO3; CH3COOH; HF

Which of the following pH is the most acidic?

A.1

B.7

C.4

D.2

A.1

Which of following is physical properties of drug?

A.polarity

B.functional group

A.polarity

drugs will behave as bases only if they contain .......... atom with a lone pair of electrons available for reaction with protons.

A.hydrogen atom

B.nitrogen atom

B.nitrogen atom

Why are not barbiturates basic drugs?

A.Because barbiturates can not produce H in aqueous solution

B.Because lone pair of electrons is not available

B.Because lone pair of electrons is not available

Which form of sulfonamide is usually administered?

A.sodium salt

B.calcium salt

A.sodium salt

Enantomers from Greek means:

A.opposite form

B.mirror image

B.mirror image

Which of the following statements is the closest description of Phase I metabolism?

A.Reactions which new functional group introduce in the molecule

B.Reactions which add a polar functional group to a drug

A.Reactions which new functional group introduce in the molecule

Which below following term include whole human blood for use in transfusion as well as blood-derived products such as clotting factors

A.blood drugs

B.blood product

C.Blood plasma

B.blood product

Partition coefficient, isomerism and ionization for drug are:

A.chemical properties

B.physical and chemical properties

A.chemical properties

Which is the salt in the following reaction,? HBr NaOH = H2O NaBr

A.NaOH

B.NaBr

B.NaBr

What is the concentration of H ions in a solution with a pH of 10.4?

A.1.0 x 10-10.4

B.3.98x10-11

A.1.0 x 10-10.4

In water solutions of which substances there is basic medium (pH > 7)

KNO2

Which of the following statements best describes pharmacokinetics

The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by various factors.

Drug solubility to cross membranes: when the drug is in stomach acid, it will pass through the stomach walls best if it is an acidic drug, neutral drug, or alkaline drug?

acidic

Which substance is reason of hot pungent taste of chilli

capsaicin

Aspirin contain functional group....

-COOH

Warfarin in free acid form is not very soluble in water and therefore is always administrated as

sodium salt

The aspirin, the anticancer compound methotrexate a and the diuretic furosemide are derivatives of ....

carboxylic acid

Barbiturates are cyclic imides used as...

hypnotics

Sulfonamides are a class of antibacterial compounds, all of which contain...

-SO2NH

Chemical compounds that have the same molecular formula but different structural formulas are

isomers

An sp3 hybridised carbon atom with four different substituents attached to it called

chiral

Why was banned Thalidomide in most countries in 1961?

Thalidomide caused birth deformities

The primary biological purpose of biotransformation is

To inactivate and detoxify drugs and other foreign compounds that may cause harm to the body

In contrast to drugs after phase I biotransformation, drugs after phase II have

Less pharmacological activity and greater water solubility

The presence of any of these functional groups EXCEPT which of the following will allow a drug to enter phase II biotransformation without first passing through phase I

Ketone (C=O)

Calculate the concentration in % (m/m) of a solution containing 20.0 g of NaCl dissolved in 250.0 g of H2O

7.41% (m/m)

The defining expression for the molarity concentration unit is

moles of solute/liters of solution

An acid-base titration involves a

neutralization reaction

In an acid-base titration, equivalent quantities of hydronium ions and hydroxide ions are present

at the endpoint

Argentometry is one from the

precipitate titration method

Na2S2O3 is titrant use in

iodimetry

Na2S2O3 is titrant use in

Redox titration

Iodimetry is used to determine

A.concentration of oxidising agents

B.water hardness

C.Aspirin

D.citric acid

A.concentration of oxidising agents

It is the branch of science that deals with study of interaction of matter with light

spectroscopy

Analytical spectroscopy is the science of determining...

how much light is absorbed or emitted by atoms or molecules within it

Light is a form of

electromagnetic radiation

The time interval during which the drug products retains the same properties & characteristics that is possessed at the time of manufacture

drug stability

Reactive free radicals join together to form

covalent bond

Most antioxidants are

phenols

Which of following statement is correct

In zero order reaction drug concentration change with constant rate

Catalyst which decrease rate of reaction is called

inhibitor

Whose objective is to protect public health by promoting the safe use of marketed medicines

Vigilance and Risk Management of Medicines Division

The aspirin, the anticancer compound methotrexate a and the diuretic furosemide are derivatives of

carboxylic acid

What is name of the process when the drug has to be transported across the membrane, against the concentration gradient, with the expenditure of energy

The process called active transport

Which of following is chemical properties of drug

partition coefficient

What is the molarity of an HCl solution if 125 mL is neutralized in a titration by 76.0 mL of 1.22 M KOH?

0.742 M

Redox indicator is substance...

a substance whose oxidized form is of different colour from that of its reduced form

KMnO4 is titrant which do not need...

indicator

How many times increase rate of reaction by increase temperature with 10 0 C?

Twice

How would HClO4 dissociate?

H ClO4-

Which functional group caused acidity of drug molecules

-COOH

Which of following is true about phenol

Phenol is weak acid