Genetic Influence and Lifetime Risk of Schizophrenia

A set of vocabulary flashcards covering the lifetime risk of schizophrenia across different degrees of genetic relatedness as presented in the lecture notes.

Parents

First degree relatives with a lifetime schizophrenia risk of $5.6\,\%$.

Siblings

First degree relatives with a lifetime schizophrenia risk of $10.1\,\%$.

Siblings with 1 parent with schizophrenia

First degree relatives with a lifetime schizophrenia risk of $16.7\,\%$.

Offspring

First degree relatives with a lifetime schizophrenia risk of $12.9\,\%$.

Offspring with 2 parents with schizophrenia

First degree relatives facing the highest lifetime risk of $46.3\,\%$.

Half-brother/half-sister

Second degree relatives with a lifetime schizophrenia risk of $4.2\,\%$.

Uncle/aunt

Second degree relatives with a lifetime schizophrenia risk of $2.4\,\%$.

Nephew/niece

Second degree relatives with a lifetime schizophrenia risk of $3.0\,\%$.

Grandchild

Second degree relatives with a lifetime schizophrenia risk of $3.7\,\%$.

Cousin

Third degree relative with a lifetime schizophrenia risk of $2.4\,\%$.

General population

The cohort with the lowest lifetime schizophrenia risk of approximately $\sim 1.0\,\%$.

Relatedness

A factor used to measure genetic influence in schizophrenia based on proximity of kinship.