soft tissue

1) diagnostic

2) histology

3) dd

4)clinique (population)

5) IHC

6) moléculaire

1) alveolar rhabdomyosarcoma

2)

• Fibrovascular cores

• Nests of small blue round tumor cells looking dyscohesive at the edge because they are fragmented

• Strap cells (elongated eosinophilic like immature muscle cells) sometimes seen

• Multinucleated wreath cells (peripheral multimuclei, muscle differentiarion)

• Rhabdomyoblasta

3)

• SBRCT

• Embryonal rms (less aggressive)

4) children and young adults

5)

• Desmin+

• MyoD + Myogenin+

6) t(1;13) or t(2;13) = PAX3-FOXO1 or PAX7-FOXO1

1) Diagnostic

2) clinique (population, zones)

3) histology

4) dd

1) botryoid embryonal rhabdomyosarcoma

2) jeunes enfants, urogenital

3)

• Polypoid

• Covered by a normal epithelium (urothelium, cervix etc…)

• Loose Spindle cells, very hypocellular with hypercellular zones frequently close to the epithelium

• Myxoid background

4) polype fibroepithelial

1)Diagnostic

2) histology

3) molecular

4) dd

1) alveolar soft part sarcoma

2)

• fibrous septeae

• Alveolar pattern

• Eosinophilic cytoplasm

• Pleomorphic nuclei, prominent nucleoli, rhabdoid/plasmacytoid aspect

3) t(X;17) = ASPRCR1-TFE3

4) metastatic renal cell carcinoma

Femme 59 ans, érythème et tumefaction de l'urètre distal

1) diagnostic

2) clinique

1) caroncule

2)