drugs acting on RAAS
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22 Terms
what drug is an example of an ACE inhibitor?
Captopril
* drugs end inn -pril
What is the MOA for ACE inhibitors?
lowers levels of antiotensin II by inhibiting ACE and increasing levels of bradykinin of kinase II
What are the therapeutic uses of captopril?
- HTN
- HF
- Acute MI
What are the adverse effects of captopril?
- AKI
- Angioedema
- Cough
- Hyperkalemia
Why should you take an ACE Inhibitor?
- HTN
- HF
- Renal vessel dilation
- MI
- neuropathy
What are the adverse effects of ACE inhibitors?
- 1st dose hypotension
- hyperkalemia
- renal failure
- cough
- angioedema
- BBW: Fetal Injury
A patient who is already taking a diuretic is also prescribed an ACE inhibitor. What drug interaction could occur?
increased risk for first does hypotension
A patient who is already taking a antihypertensive is also prescribed an ACE inhibitor. What drug interaction could occur?
toxic accumulation of lithium
A patient who is already taking a nonsteroidal anti-inflammatory is also prescribed an ACE inhibitor. What drug interaction could occur?
lowers hypertensive effects of ACE inhibitors
What prototype drug is an Angiotensin II receptor blocker (ARBS)?
Losartan (Cozaar)
What is the MOA for ARBS?
selective and competitive blockade of angiotensin II
What are ARBS used to treat/prevent?
- HTN
- MI
- HF
- Diabetic nephropathy
What are the adverse effects of ARBs?
- renal failure
- cough
- angioedema
- fetal injury
What is an example of aldosterone antagonists?
Spiralactone and Eplenone (Inspra)
MOA for Aldosterone Antagonists?
selective blockade of aldosterone receptors
what are the therapeutic uses of aldosterone antagonists?
- HTN
- HF
What are the adverse effects of aldosterone antagonists?
Hyperkalemia
Drug interactions for aldosterone antagonists
CYP3A4 leads to increased levels of eplerenone
What is an example of Direct Renin Inhibitors?
Aliskiren (Tekturna)
What is the MOA for Direct Renin Inhibitors?
binds tightly to renin to inhibit cleavage of angiotensin to angiotensin I
Therapeutic uses for direct renin inhibitors?
hypertension
adverse effects of direct renin inhibitors?
- hyperkalemia
- diarrhea
- cough
- fetal injury
- angioedema