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urinary system, digestive system, respiratory system, reproductive system, pharmacology
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glomerulus
where filtration occurs
convoluted tubules and loop of Henle
where reabsorption occurs
collecting duct
were urine/filtrate are secreted to move to bladder for storage before voiding re
obligatory reabsorption of water (fixed)
reabsorption of water for proximal tubule and loop of Henle
facultative reabsorption of water (variable)
reabsorption of water for distal tubule and collecting duct
ureters
move urine from kidneys to bladder
urinary bladder
stores urine
urethra
tube connecting bladder to outside
detrusor muscle
smooth muscle layer contracting and relaxing based on urine volume
internal sphincter
made of smooth muscle, involuntary control
external sphincter
made of skeletal muscle, voluntary control
storage phase
sympathetic nervous system relaxes detrusor muscle and contracts internal sphincter, somatic nervous system contracts external sphincter
micturition
urination/voiding of urine
voiding phase
parasympathetic nervous system contracts detrusor muscle to release urine, sympathetic nervous system relaxes internal sphincter, somatic nervous system relaxes external sphincter
RAAS
renin-angiotensinogen-aldosterone-system
angiotensin converting enzyme (ACE)
from lungs, converts angiotensin I into angiotensin II
renin
from kidneys, converts angiotensinogen into angiotensin I
ANP
from atrium of heart
BNP
from ventricles of heart
antidiuretic hormone (ADH)
hormone regulating water balance, released from hypothalamus
calcitonin
released from thyroid gland, lowers calcium levels
parathyroid hormone (PTH)
released from parathyroid gland, increases calcium levels
calcitriol
increases calcium reabsorption from dietary intake, released from kidneys
Erythropoietin (EPO)
released by kidneys and regulates RBC production in bone marrow
osmosis
movement of water from an area of low solute concentration to an area of high solute concentration
glomerular hydrostatic pressure
pressure that forces material out of blood and into renal tubule via diffusion
capsular hydrostatic pressure
pressure of fluid inside Bowman’s capsule against GHP
colloid osmotic pressure
proteins in glomerular capillaries try to draw fluid back from Bowman’s capsule
nasal cavity function
channels air into pharynx, warms and moistens air
nasal cavity form
mucous membranes, highly vascular
pharynx function
channels air into larynx, warms and moistens air
pharynx form
mucous membrane, L-shaped bend, highly vascular
larynx function
channels air into trachea, modulate vocalisations, excludes solids and liquids from oesophagus
larynx form
rings of cartilage and muscle, glottis, laryngeal muscles (sound control) and epiglottis
trachea function
channels air into lungs
trachea form
flexible tube, anterior to oesophagus
bronchus
“branches” coming from trachea into lungs
alveolar
composed of multiple alveoli
bronchioles
composed of multiple alveolar
vascular epithelium
warms cold air because it is highly vascular
mucous membrane
damp and stick, moistens dry air
nasal conchae
L-shaped bend in pharynx ensures air spends more time in contact with vascular epithelium and mucous membranes
sneeze reflex
triggered by irritation of nasal mucosa, expels irritants
alveolar macrophages
embedded in alveoli walls, destroys particulates and pathogens
mucociliary escalator
ciliated goblet cells sweep debris towards pharynx to be expelled or swallowed
tonsils
detect and tap inhaled pathogens and flush them via lymphatic system
pressure
the more stuff in the container, the more pressure the stuff exerts on the container
pressure gradient
movement of substances from area of high pressure to low pressure
competing pressures
divider moved by pressure gradient until pressure is equal
quiet/tidal breathing
breathing under normal circumstances
visceral pleura
pleura stuck to lungs
parietal pleura
pleura stuck to ribs and diaphragm
intrapleural cavity
cavity between lungs and ribs
inhalation
diaphragm pulls down, intrapleural cavity expands, lungs expand, air moves into lungs
exhalation
diaphragm relaxes, intrapleural cavity constricts, lungs constrict, air moves out of lungs
ventilation rate
volume moved with each inhalation or exhalation x breaths per minute
forced breathing
active manipulation of breathing that uses inspiratory and expiratory reserve volume
external respiration
occurs between lungs (alveoli) and blood supply
internal respiration
occurs between blood supply and cells/systemic tissues
conducting zone
passage moving air into and out of lungs
respiratory zone
involved in gas exchange directly
chemoreceptors
detect gas levels and adjust alveolar ventilation rate and depth
baroreceptors
detect changes in pressure and vasodilate/constrict blood vessels
chemo/mechano receptors
detect irritants and cause cough/sneeze reflex
pontine respiratory group, vental respiratory group, dorsal respiratory group
brain autonomic respiratory centers
cerebral motor cortex, pons and medulla oblongata
voluntary control of respiratory system
ingestion
occurs when food/liquid enters the digestive tract via the oral cavity
secretion
release of water, acids, enzymes, buffers and salts from the epithelium of the digestive tract and glandular organs into the digestive tract
mechanical processing
physical breakdown of food into smaller particles that make materials easier to propel along the digestive tract
digestion
chemical breakdown of food into small organic fragments suitable for absorption by the digestive epithelium
absorption
the movement of organic molecules, electrolytes, vitamins and water across the digestive tract, then into the blood or lymph
defecation
eliminations of wastes, indigestible substances, bacteria, dead cells from the body etc
mucosa
inner lining of digestive tract consisting of epithelium and moistened by glandular secretions
submucosa
dense, irregular connective tissue binding mucosa to muscularis externa
muscularis externa
inner circular layer of smooth muscle essential for agitation and formations of valves. essential for mechanical processes such as peristalsis and segmentation
serosa
outermost layer of epithelium which covers the muscularis externa along with most portions of the digestive tract
accessory organs
liver, gall bladder, pancreas
mastication (chewing)
uses teeth, tongue, palate to manipulate food and increase surface area of food particles to come into contact with digestive enzymes in saliva, for example
peristalsis
waves of muscular contractions that move bolus along digestive tract
chemical digestion
where digestive enzymes break the bonds between component molecules of organic molecules
lipid digestion
triglycerides into monoglycerides and fatty acids
carbohydrate digestion
polysaccharides into monosaccharides
protein digestion
polypeptides into amino acids
catabolism
break down of larger/complex molecules into smaller ones, releasing energy
anabolism
use of simple molecules to make larger organic molecules, which consume energy
basal metabolic rate
minimum resting energy expenditure of an awake, alert person
dephosphorylated
ATP → ADP + Pi
phosphorylated
ADP + Pi → ATP
glycolysis
occurs in cytosol, converts glucose into 2 pyruvate, resulting in net gain of 2 ATP
Kreb’s cycle
occurs in mitochondrial matrix, produces 2 ATP from 1 glucose
electron transfer chain
occurs in mitochondrial cristae, pumps hydrogen ions and produces 26-28 ATP
glycogenolysis
stored glycogen release glucose into bloodstream when glucose levels decrease, activated by glucagon
glycogenesis
2 glucose molecules join together and are stored in liver and skeletal muscle cells, triggered by insulin
gluconeogenesis
production of glucose triggered by glucagon and cortisol
lipolysis
triglycerides broken down into 1 glycerol and 3 fatty acids to enter the Kreb’s cycle
lipogenesis
occurs in liver, glucose or amino acids can be converted and assembled into triglycerides