Vaccination

What do antigens activate in the adaptive response

production of antibodies and T-cells

Do vaccinations cause disease

no (sometimes)

what Ig is used for humoral blood borne pathogen s

IgG

what immune responses do vaccines aim for

CTL mediated

Features of Vaccines

• Safe

• Protective

• Induces Neutralizing AB

• Induces T cells

How do live attenuated vaccines work

Reduces the virulence of pathogen whilst retaining antigens that can promote an immune response

what is live attenuated vaccines used for

polio, mumps, measles, rubella, rabies

Can immune compromised patients get live attenuated vaccines

NAUR

Differneces between the Sabin and Salk polio vaccine

Sabin - live and oral - stimulates IgA production and more mucosal immunity - can revert

Salk - inactive and injected - less mucosal immity - cannot revert

Inactivated vaccines

cannot replicate and do not persist as long - may not induce protective immunity to the same extent

What vaccines are inactive

flu, typhoid, hep A, salk polio

Subunit vaccines

contain parts of the pathogen - molecules or inactivated toxins (toxoids)

safe to use and produce

Examples of the subunit vaccines

human papilloma virus (HPV) , and tetnus taxoid