Ophthalmic, Nasal, and Otic

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9 Terms

1
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What is the primary tissue barrier to drug absorption after topical ophthalmic administration?

cornea

2
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What factors affect ocular bioavailability?

Solubility, permeability, tear volume, formulation pH, drug pKa

3
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What form of drugs are commonly delivered as eye drops?

small chemical drugs

4
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What are the effects of nasal spray and otic formulations?

Nasal: local and systemic; Otic: usually local

5
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What drugs are commonly used to treat ear conditions?

Antibiotics, steroids, antifungals, local anesthetics, cerumenolytics

6
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What is the BUD for non-preserved aqueous formulations?

14 days

7
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What is the BUD for preserved aqueous formulations?

35 days

8
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What is the BUD for non-aqueous oral formulations?

90 days

9
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What is the BUD for non-aqueous non-oral formulations?

180 days