35: Personalized and Precision Medicine

precision medicine:

• data driven, stratified approach

• uses biomarkers + molecular profiles to predict therapeutic response

• integrates genomics, proteomics and metabolomics

• support by computational tools and AI

personalized medicine:

• tailoring therapy to individual characteristics

• uses patient genetics, lifestyle, environment

• goal is to optimize outcomes + minimize adverse events

Which immunologic outcome was observed in responders to the personalized mRNA neoantigen vaccine?

vaccine-expanded T cells constituted up to ~10% of circulating T cells

What proportion of patients in the mKRAS off-the-shelf vaccine trial developed direct ex vivo KRAS-specific T-cell responses?

84%

off-the-shelf KRAS-mutant peptide vaccines:

non-personalized vaccine targeting common oncogenic mutations that can evoke robust immune responses

Integrating precision medicine into pharmacy practice can lead to what type of improvements?

enhanced optimization of medication regimens for patients