Biol 266 Kahoot : Cell Signaling -- 2

Which mechanism is not involved in the inactivation of an activated RTK?

Dephosphorylation by protein tyrosine phosphatases

Dephosphorylation by protein serine/threonine phosphatases

Removal of the RTK by endocytosis

Digestion of the RTK in lysosomes

Dephosphorylation by protein serine/threonine phosphatases

Which G protein leads to the production of cAMP as a second messenger?

Gs

Gi

Gq

Ga

Gs

cAMP mediates its cellular effects via the activation of:

Protein kinase A

Protein kinase B

Phospholipase C

PI3K

Protein kinase A

In the Raf kinase phosphorylation cascade, the final kinase to be activated is:

Raf

Mek

Erk

MAPKKK

Erk

Activated phospholipase C directly generates:

DAG + PIP3

DAG + IP3

PIP2 + PIP3

DAG + IP3 + Ca2+

DAG + IP3

Ca2+ mediates most of its cellular effects by:

Directly activating kinases

Binding to phospholipids in the membrane

Binding to cAMP

Binding to Ca2+-responsive proteins

Binding to Ca2+-responsive proteins

A drug has been designed that activates GPCRs associated with Gi proteins. What will be the consequence of drug binding?

Increased cAMP inside the cell

Increased Ca2+ inside the cell

Decreased cAMP inside the cell

Decreased IP3 inside the cell

Decreased cAMP inside the cell

Place the events involved in the Ras-Raf RTK pathway in the correct order.

Receptor dimerization

Receptor autophosphorylation

Recruitment of Grb2 to the receptor

Activation of Ras

Receptor dimerization

Receptor autophosphorylation

Recruitment of Grb2 to the receptor

Activation of Ras

Phospholipase C cleaves ______ to generate DAG and IP3.

PI 4,5-bisphosphate (PIP2)

PI 3,4-bisphosphate

PI 3,4,5-triphosphate (PIP3)

PI

PI 4,5-bisphosphate (PIP2)