Week 6 Online Homework

Check the mRNA and amino acid sequence in the figure above. Which of the following mRNAs represents an alternative mRNA sequence that would not change the amino acid sequence as a consequence of the redundancy of the genetic code?

5'-AUG-GCU-AAC-GAU-UUC-CAG-UAA-3'

What is the amino acid sequence that corresponds to the following abbreviated DNA sequence taken from the middle of a gene?

YES

The different coat colors of the two mouse phenotypes are directly caused by _________.

differences in the protein amino acid sequence

The phenotypic variation in the trait "coat color" in mice is passed from a parent to their offspring via _______________.

differences in DNA sequences in different parents

Which of the following statements about mutations are true?

Mutations are the only source for the origin of new alleles.

Both substitution and indel mutations could result in a non-sense mutation in the affected codon following the mutational event.

Consider the wild-type DNA sequence:  ^3' ATACTTTCA ^5'.  (Only the transcribed strand is shown).

Which of the following shows an indel mutation of the wild-type DNA sequence shown above that does NOT result in a frameshift mutation?

ATA[‘’’]TCA

A[‘’’]TTTCA

Write ONE of the possible DNA sequences of the transcribed strand shown above that results from BOTH a single substitution mutation of the first codon AFTER the start codon that would also cause a nonsense mutation.

ATACATTCA

Allele 1

Allele 2

Allele 3

Allele 4

[substitution] [missense] [not enough information]

[substitution] [nonsense] [non‑functional protein product]

[deletion] [frameshift] [non‑functional protein product]

[substitution] [silent] [no effect]

Find the specific gene loci for the EDA gene and for the EDAR gene in humans and annotate the human karyotype for each locus

The patient's EDA gene sequence has a SNP located at nucleotide number _____. The mutation that caused this SNP was a _____ mutation by cause and a _____ mutation by effect and affects the _____^t codon of the EDA gene.

993, substitution, missense, 331