Lesson 3 - 3rd line of defense, T and B cells

Which of the following apply best to the specific/adaptive immune system?

produce immunological memory

systemic effect

Humoral immunity

Antibodies

Cellular immunity

T-cells

Active

Patient gets vaccine. Produces memory T and B cells.

Active

Patient gets infected. Produces memory T and B cells.

Passive

Baby gets antibodies from mother.

Passive

Receiving antibodies that you didn't make through injection. Temporary protection until antibodies are cleared from body.

Antigenic molecules tend to need to be relatively

Large

B cells

Become immunocompetent in RBM. Have ability to produce antibodies.

T cells

Become immunocompetent in thymus. Have ability to directly kill pathogenic cells or infected cells.

MHC

Proteins unique to you that all cells in your body have. How your immune system recognizes 'self'.

APC

Leukocytes that present foreign antigens from endocytosed cells on their MHC proteins to T-cells.

T-cell activation

T cell with correct receptor docks to APC. Signaled to undergo rounds of mitosis to make a clone army of T cells with correct receptor for antigen.

Antigen presentation

APC with antigen displayed on MHC protein goes to Lymph node. T-cells check to see if they have the correct receptor for it.

Primary response

1st exposure and mounting of immune response

T-h cells

coordinate attack. Summon NK cells, neutrophils, macrophages....

Secondary response

Memory T cells patrol body with ability to mount very fast response to next infection so you don't get sick.

T-c cells

directly kill enemy/infected cells with cytotoxic chemicals

When this happens the T-h cell gives signal to B cell to undergo mitosis and make clone army of itself.

B cell displays fragments of antigen on it's MHC proteins and presents them to T-h cell. In this way the B cell acts as an APC.

Activated B cell clones do this.

B cells convert into plasma cells and produce massive amounts of antibodies for the next few days.

When this happens the B cell endocytoses the antigen.

B cell receptors bind to antigen that has complementary shape to the B cell's receptors.