IBD Treatments: Biologics, Immunomodulators, and Symptom Management

Remicade

Infliximab

Infusion

CD/UC

Biologic Anti TNF

Zymfentra

Infliximab-dyyb

Injection

CD/UC

Biologic Anti TNF

Humira

Adalimumab

Injection

CD/UC

Biologic Anti TNF

*Biosimilar: Amjevita

Cimzia

Certolizumab Pegol

Injection

CD

Biologic Anti TNF

Simponi

Golimumab

Injection

UC

Biologic Anti TNF

Entyvio

Vedolizumab

Infusion/Injection

UC

Biologic Anti-Integrin

Tysabri

Natalizumab

Infusion

CD

Biologic Anti-Integrin

Tremfya

Guselkumab

Injection only for IBD

CD/UC

IL23

Stelara

Ustekinumab

Infusion to start - move to injection

CD/UC

IL12/IL23

Skyrizi

Risankizumab

Infusion to start - move to injection

CD/UC

IL23

Omvoh

Mirikizumab

Infusion to start - move to injection

CD/UC

IL23

Xeljanz

Tofacitinib

Oral

UC

Biologic JAK-Inhibitor

Rinvoq

Upadacitinib

Oral

CD/UC

Biologic JAK-Inhibitor

Colestid

Colestipol

Oral

1st used when treating symptoms

Bile salt/Acid binder

Questran

Cholestyramine

Oral

1st used when treating symptoms

Bile salt/Acid binder

Padiapred Oral/Liquid Omnipred

Prednisone

Oral/infusion/rectal

Treat flare ups and symptoms - meant to be short term

Corticosteroids

Depo-Medrol/Solu-Medrol/Medrol

Methylprednisolone

Oral

Treat flare ups and symptoms - meant to be short term

Corticosteroids

Entocort/Uceris

Budesonide

*Entocort digested in ileum

*Uceris digested in colon

Oral/rectal/infusion

Treat flare ups and symptoms - meant to be short term

Corticosteroids

Prograf

Tacrolimus

Oral

Treat ongoing inflammation and maintain remission

Immunomodulators

Deltasone

Prednisone

Oral/rectal/infusion

Treat flare ups and symptoms - meant to be short term

Corticosteroids

Cortenema/Cortifoam

Hydrocortisone

Enema

Treat flare ups and symptoms - meant to be short term

Corticosteroids

Azulfidine

Sulfasalazine

Oral/rectal

Treat symptoms - mainly decrease inflammation

Aminosalicylates (5-ASA)

Lialda/Delzicol/Apriso/Asacol/Pentasa/Rowasa

Mesalamine

Oral

Treat symptoms - mainly decrease inflammation

Aminosalicylates (5-ASA)

Methotrexate

Methotrexate

Oral/Injection

Treat ongoing inflammation and maintain remission

Immunomodulators

Canasa

Mesalamine

Rectal

Treat symptoms - mainly decrease inflammation

Aminosalicylates (5-ASA)

Neoral

Cyclosporine

Oral/Infusion

Treat ongoing inflammation and maintain remission

Immunomodulators

Dipentum

Olsalazine

Oral

Treat symptoms - mainly decrease inflammation

Aminosalicylates (5-ASA)

Azasan/Imuran

Azathioprine

Oral

Treat ongoing inflammation and maintain remission

Immunomodulators

Colazal/Giazo

Balsalazide

Oral

Treat symptoms - mainly decrease inflammation

Aminosalicylates (5-ASA)

Flagyl

Metronidazole

Oral/Infusion

1st used when treating symptoms - often before diagnosis

Antibiotics

Cipro/Proquin

Ciprofloxacin

Oral/Infusion

1st used when treating symptoms - often before diagnosis

Antibiotics

Velsipity

Etrasimod

Oral

UC

S1P Receptors

Xifaxan

Rifaximin

Oral

1st used when treating symptoms - often before diagnosis

Antibiotics

Zeposia

Ozanimod

Oral

UC

S1P Receptors

Imodium/Diamode

Loperamide

Oral

1st used when treating symptoms - often before diagnosis

Anti-diarrheals

Lomotil

Diphenoxylate-atropine

Oral

1st used when treating symptoms - often before diagnosis

Anti-diarrheals