BMFD 1 Apoptosis

Unprogrammed Cell death

Necrosis

Programmed Apoptotic Cell death

Apoptosis

Programmed Non-Apoptotic Cell death

Autophagy

Plasma membrane during Necrosis:

ruptures & releases cell contents

Plasma membrane during apoptosis:

membrane blabbing & maintains integrity

Nucleus during Necrosis:

some chromatin condensation

Nucleus during apoptosis:

Very distinct chromatin condensation

Other cytoplasmic organelles during Necrosis:

swelling

other cytoplasmic organelles during apoptosis:

minor changes

Necrosis forms __ apoptotic bodies.

no

Apoptosis forms ___ apoptotic bodies.

many

Necrosis ___ cause inflammation.

does

Apoptosis ____ ____ cause inflammation.

does not

Cells commits to necrosis due to ___ ____.

irreparable damage

Possible causes of the irreparable damage are:

poison & toxins, mechanical injuries (cutting, crushing), & physical injuries (radiation)

During Necrosis cells swell due to ___ of normal ____ ____.

loss, ion regulation

Cells contents leak into the ____ ___ & begin the ____ response.

extracellular space, inflammatory

Necrosis causes ____ of cell organelles.

disruption (swelling & leakage)

The organelles that get swelling and leakage include:

ER, lysosomes, mitochondria, nucleus, and Golgi

Membrane blebs are ____ prominent in necrotic cells.

less

Free lysosomal enzymes contribute to the degradation of ____ ___ & _____.

nucleic acids, proteins

Final stage of necrosis is ___ of the plasma membrane.

rupture

The release of ____ cause ___ and activation of immune cells.

decay products, inflammation

Which cell death is the preferred choice?

apoptosis

Apoptosis has two pathways the ___ and the ____.

extrinsic, intrinsic

The extrinsic pathway death signal comes from ___ the cell.

outside

The intrinsic pathways signal comes from ___ the cell.

inside

Death receptors are members of the ____ receptor superfamily.

tumor necrosis factor (TNF)

Death receptors are activated by ___ ___ and may trigger signaling pathways that promote cell ____ or ____.

specific ligands, death, survival

The Fas Ligand binding to the Fas receptor activates the ___ pathway.

Apoptotic

Fas ligand is a ____ proteins belonging to the TNF family.

transmembrane

The Fas Ligand is found on the ___ cell.

Killing

Fas ligand binds to the ____ ____ to induce cell death.

Fas receptor

Fas receptor is found on the ___ cell.

dying

Fas receptor is a member of ___ family.

Tumor necrosis factor (TNF)

Fas receptor is a transmmebrane protein that binds to ____.

Fas Ligand

The intracellular region of ____ contains a ___ ___ that allows recruitment of proteins involved in apoptosis.