🧬Hormones and Cells with Receptors

Where is CRH produced?

Hypothalamus

What type of hormone is CRH?

Protein/peptide hormone

What receptor does CRH bind to?

CRHR-1 (Gs-linked GPCR)

Where is the CRH receptor located?

Anterior pituitary on corticotrophs

CRH stimulates the synthesis and release of which hormone from the anterior pituitary?

ACTH

What type of hormone is ACTH?

Peptide hormone

What receptor does ACTH bind to?

MC2R (Gs-linked GPCR)

Where is the ACTH receptor located?

Adrenal gland on adrenal cortical cells

Where is GnRH produced?

Hypothalamus

What type of hormone is GnRH?

Protein/peptide hormone

What receptor does GnRH bind to?

GnRHR (Gq-linked GPCR)

Where is the GnRH receptor located?

Anterior pituitary on gonadotrophs

GnRH causes synthesis and release of what 2 hormones?

FSH and LH

What type of hormone is FSH and LH?

Glycoprotein

What receptor does FSH bind to?

FSHR (Gs-linked GPCR)

Where is the FSH receptor located?

Testis on Sertoli cells

What receptor does LH bind to?

LHCGR (Gs-linked GPCR)

Where is the LH receptor located?

Testis on Leydig cells

Where is GHRH produced?

Hypothalamus

What type of hormone is GHRH?

Peptide hormone

What receptor does GHRH bind to?

GHRHR (Gs-linked GPCR)

Where is the GHRH receptor located?

Anterior pituitary on somatotrophs

Where is somatostatin produced?

Hypothalamus

What does somatostatin do?

Inhibits GH release

What type of hormone is somatostatin (SS)?

Peptide hormone

What receptor does somatostatin bind to?

SS receptor (Gi-linked GPCR)

Where is the somatostatin receptor located?

Anterior pituitary on somatotrophs

GHRH drives synthesis and release of what hormone from the anterior pituitary?

GH (growth hormone)

What type of hormone is GH?

Protein hormone

What receptor does GH bind to?

GH receptor (JAK-STAT)

Where is the GH receptor located?

Liver on hepatocytes

Where is TRH produced?

Hypothalamus

What type of hormone is TRH?

Peptide hormone

What receptor does TRH bind to?

TRHR (Gq-linked GPCR)

Where is the TRH receptor located?

Anterior pituitary on thyrotrophs

What hormone produced by the hypothalamus inhibits release of TRH?

SS (somatostatin) on thyrotrophs

TRH drives synthesis of what hormone?

TSH

What type of hormone is TSH?

Glycoprotein

What receptor does TSH bind to?

TSH receptor (Gs-linked GPCR)

Where is the TSH receptor located?

Thyroid gland on follicular cells

What inhibitory hormone is produced by the hypothalamus inhibits prolactin release?

Dopamine

What type of hormone is dopamine?

Catecholamine

What receptor does dopamine bind to?

D2 receptor (Gi-linked GPCR)

Where is the dopamine receptor located?

Anterior pituitary on lactotrophs

Dopamine inhibits release of what hormone?

Prolactin

What type of hormone is prolactin?

Protein hormone

What receptor does prolactin bind to?

PRL receptor (JAK-STAT)

Where is the prolactin receptor located?

Mammary glands on alveolar epithelial cells