Phosphorus

Major intracellular fluid which is inversely related to calcium, distributed 85% in bones and teeth, 15% in ICF

Phosphorus

Phosphorus role in the body:

role in ___________ activity

durability of ________ and _______

Neuromuscular activity

Bones and Teeth

It is excreted 90% in the _______ and 10% in _____________

Kidneys

GI secretion

Regulator that lowers Phosphate conc by increasing renal excretion

Parathyroid HormoneI

Regulator that increases Phosphate conc by reabsorption in the kidney

Vitamin D

Regulator that increases Phosphate conc by regulation of skeletal growth

Growth Hormone

Clinical application of Phosphorus where alcohol abuse is the most common, it also includes Vit. D deficiency and hypethyroidism

Hypophosphatemia

Clinical application of Phosphorus that causes renal failure due to increased phosphate intake and increased cellular phosphate release. It also increases the breakdown of cells

Hyperphosphatemia

Specimens used for Phosphorus

Serum

Plasma

24-hour urine

Inteferences:

Do not use __________, ______, and _______ which tends to false decrease the level of phosphorus

do not used __________ specimen because it gives a false increased result

Oxalate, Citrate, EDTA

Hemolyzed Specimen

Method of Measurement of Phosphorus that uses a conversion of inorganic phosphate to heteromolybdenum blue by reacting with ammonium molybdate

Fiske-Subbarow method

Phosphorus is read at ______ nm

600 nm

Reference interval of Pjosphorus

0.81 - 1.62 mmol/L

2.5-5.0 mg/dL

Normal Value for Adults

2.5-4.5 mg/dL

0.81-1.46 mmol/L

Normal Value for Children

3.5-6.5 mmol/L

1.13-2.11 mmol/L

Phosphorus Calculation:

Conventional Unit

Si Unit

Abs of Sample / Abs of Standard x 5

mg/dL x 0.324