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Griffith - Process
Live S - dies
Live R - lives
Heat killed S - lives
Heat killed S + live R - dies + live S inside
Griffith - Pneumococci
Rough - avirulent
Smooth - virulent + sugar coat
Griffith - Findings
Heat killed S transfer genetic info to live R
Code to make protective coat
Bacteria change physical traits
Avery - Findings
Purify/separate transforming factor/extract from S cell
DNA transfer virulence - not protein
Hershey & Chase - Process
Mix T2 bacteriophage with E coli
Centrifuge
32P DNA - radioactivity in host
35S Protein - radioactivity in phage ghosts
Hershey & Chase - Findings
DNA genetic material - NOT protein
Watson & Crick - 2 Evidence
X ray diffraction
Chargraffs rules
Purine
A
G
Pyrimidine
C
T
U
Nucleoside
Base + sugar