PHARM 2: post midterm practice Q

JESSICA

which of the following is not a clinical application of benzodiazepines

a. acute anxiety states

b. general anxiety disorder

c. skeletal muscle relaxation

d. seizure disorder

e. insomnia

f. Parkinson

f. parkinson

L27 anxiety and sleep disorder

which of the following is not a benzodiazepine drug

a. alprazom

b. clonazepam

c. lorazepam

d. diazepam

e. triazopam

e. triazopam

(made up)

L27 anxiety and sleep disorder

A patient is taking alprazolam (benzodiazepine) for panic attacks but took too many and is now overdosing on it. What is the antidote drug to reverse these effects?

a. midazolam

b. flumazenil

c. zolpidem

d. butabarbital

b. flumazenil

antidote for OD on benzo

L27 anxiety and sleep disorder

name the drug class that has this MOA: bind to GABAa receptor subunit to facilitate chloride opening and increase frequency

a. benzodiazepines

b. benzothiazines antagonist

c. hypnotics

d. H1 receptors

a. benzodiazepines

L27 anxiety and sleep disorder

Lipid soluble drugs enter the central nervous system

a. fast

b. slow

a. fast

L27 anxiety and sleep disorder

some drugs have active metabolites with long half life which can accumlate and cause excess sedation. this is problematic for which age group

a. infants

b. teenagers

c. elderly

d. new parents

c. elderly

L27 anxiety and sleep disorder

which neurotransmitter is most assoicated with inhibition in the CNS

a. norepineprhine

b. serotonin

c. GABA

d. dopamine

c. GABA

L27 anxiety and sleep disorder

where does GABA bind on the ion channel

a. between alpha and gamma

b. between alpha and beta

c. within the membrane channel

d. goes through the chloride channel

b. between alpha and beta

where is GABAa NOT located

a. thalamus

b. limbic structures

c. cerebellar cortex

d. cerebral cortex

c. cerebellar cortex

where does benzodiazepines bind

a. between alpha and gamma

b. between alpha and beta

c. between a1 and y2 subunits

d. goes through the chloride channel

c. between a1 and y2 subunits

benzodiazepines binding facilitates the inhibitory actions of GABA by:

a. decreased frequency of GABA chloride ion channel opening

b. increased frequency of GABA chloride ion channel opening

c. constant frequency of GABA chloride ion channel opening

d. membrane hypo polarization

b. increased frequency of GABA chloride ion channel opening

what is the drug used to reverse benzodiazepine and its CNS affects

a. flumazenil

b. gaba agonist

c. norepinephrine

d. noxolone

a. flumazenil

which of the following is the inverse agonist of benzodiazepine which have high affinity for BZ receptors.

a. acarbose

b. a-carboline

c. lispro

d. fluconazole

b. a-carboline

which of the following drug class MOA is to increase the duration of GABA-mediated chloride ion channel opening

a. barbituates

b. benzodiapenes

c. new hypnotics

d. zolpidems

a. barbituates

barbituates can or cannot be reversed by flumazenil

a. can

b. cannot

cannot

because uses different binding sites

which of the following is not considered one of the "z" drugs

a. zolpidem

b. zaleplon

c. eszopiclone

d. zaditor

d. zaditor

true or false: Z drugs interact with certain benzo receptors

true; still not considered a benzo drug tho

can the effects Z drugs be reversed by flumazenil?

a. yes

b. no

a. yes; since it interacts with certain benzo receptors

where do benzo bind on the GABAA receptor

a. between B and Y subunits

b. between a and b subunits

c. between a and y subunits

d. between a and a subunits

c. between a and y subunits

which of the following best describes the mechanism of sedative action of benzo

a. activate GABAb receptors in the spinal cord

b. stimulate release of GABA from nerve endings in the brain

c. increase frequency of opening chloride ion channels associated with GABAa receptors

d. inhibit GABA transaminase to increase brain levels of GABA

c. increase frequency of opening chloride ion channels associated with GABAa receptors

Flumazenil will counteract the action of each of the following drugs except:

a. alprazolam

b. buspirone

c. diazepam

d. eszopiclone

b. buspirone

which drugs are classified as selective for the GABAa receptor isoform containing a1 subunit

a. benzodiazepines

b. barbiturates

c. zolpidem, zaleplon, eszopiclone

d. baclofen

c. zolpidem, zaleplon, eszopiclone

what is the primary mechanism by which benzo enhance GABA effect

increase duration of channel opening

flumazenil acts as an antagonist at which receptor

benzo

which drug class is preferred for rapid control of panic attacks

a. beta blockers

b. eszopiclone

c. benzodiazepines

d. zolpidem

c. benzodiazepines

which of the following benzo drugs have greater long term efficacy for panic and phobic disorders (select 2)

a. alprazolam

b. clonazepam

c. diazepam

d. zaleplon

a. alprazolam

b. clonazepam

which medical condition has seen an incresing use of newer antidepressants for treatment, as opposed to traditional benzos

a. acute anxiety states

b. chronic anxiety states

c. insomnia

d. muscle spasticity

b. chronic anxiety states

a 40 year old woman has occasional acute attacks of intense anxiety with marked physical symptoms, including hypertension, tachycardia, and sweating. if she is diagnosed as suffering from panic disorder, the most appropriate drug to use is: (select 2)

a. alprazolam

b. eszopiclone

c. flurazepam

d. propranolol

e. clonazepam

a. alprazolam

e. clonazepam

what is a primary concern regarding the use of ebnzo in older patients

a. overdose risk

b. increased heart rate

c. greater sensitivity to CNS depressant effects

d. high potential for addiction

c. greater sensitivity to CNS depressant effects

among the following drugs, which is noted for having minimal effects on sleep patterns and less daytime cognitive impairment compared to traditional benzo

a. flurazepam

b. diazepam

c. zolpidem

d. midazolam

c. zolpidem

sedative hypnotic drugs are generally not recommended for which of the following sleep disorders

a. insomnia

b. sleep apnea

c. parasomnia

d. circadian rhythm disorders

b. sleep apnea

long acting benzo are primarily used in the manage of withdrawal states in individuals dependent on which substance

a. opioids

b. cocaine

c. ethanol

d. stimulants

c. ethanol

which antidepressant primarily exert their effects through antagonism of the 5-HT2A receptor

a. SSRI

b. Tricyclic antidepressants

c. nefazodone and trazodone

d. monamine oxidase inhibitors

C. nefazodone and trazodone

which of the following drugs is most likely to be of value in obsessive compulsive disorders

a. amitripyline

b. bupropion

c. fluoxetine

d. trazodone

e. venlafaxine

c. fluoxetine