Chapter 14: Injury and Illness

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Moderate pain

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88 Terms

1

Moderate pain

________ can be treated by combining a mild opioid with aspirin or an NSAID.

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Antiepileptic agents

________: used for treating epilepsy but are also used to treat neuropathic pain and fibromyalgia.

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Viral Tat a protein

________ released by HIV- infected cells that is suspected of neurotoxicity.

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Acetaminophen

________: has analgesic properties but does not reduce inflammation.

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Immunotherapy

________: using the bodys own immune system against the tumor.

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level of recovery

The ________ depends a lot on whether the tasks are practiced after injury.

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Decompressive craniectomy

________: removal of part of the skull to allow the brain space to swell.

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Chemotherapy

________ destroys tumor cells that remain after surgery and radiation.

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Gliomas

________: brain and spinal cord tumors originating in and comprised of cancerous glial cells.

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Life prolonging drugs

________ make HIV a chronic illness instead of a death sentence in the US.

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Anti angiogenic therapy

________: restricting the tumors blood supply.

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Steroids

________ may be effective in shortening attacks.

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HAND

________ may be related to secreted viral products or cytokines.

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Seizures

________: occur due to sudden, disorderly changes in interconnected brain neurons.

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growth factors

Administering ________ may further enhance the benefits of stem cell transplantation.

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Opioids

________ have a high potential for abuse.

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Placebos

________ and hypnosis can significantly reduce pain.

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Radiation

________ can be used to stop a tumors growth or cause it to shrink.

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Nociceptors

________: peripheral nerve fibers that initially respond to an injury stimulus.

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CART

________ (combination antiretroviral treatment): a cocktail of 3+ drugs that are meant to work against HIV.

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Chlorotoxin

________: a scorpion- derived toxin that can interfere with the spread of tumor.

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spinal cord injuries

Traumatic brain & ________ can lead to significant disabilities and death.

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spinal cord

Injecting morphine into the ________ produced large pain control in animal tests.

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Rogesterone

Administering ________ cut the number of deaths in severely injured patients by 50 %.

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Virus

________ triggers sensory neuropathy by releasing neurotoxins.

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Antidepressants

________: used for treating depression, chronic, and neuropathic pain.

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tumor

The expanding ________ can increase the pressure in the skull.

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Opioid receptors

________ are concentrated in the spinal cord.

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Stroke

________: occurs when a blood vessel bringing oxygen and nutrients bursts or is clogged by a blood clot or some other particle.

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Surgery

________ is an option for patients with specific partial seizures who dont respond to antiepileptic drugs.

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Partial epilepsies

________ are harder to treat.

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effects of stroke

The ________ are location- dependent.

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HIV

________ is the prime mover in HAND.

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Nonopioids

________: aspirin and NSAIDs (nonsteroidal anti- inflammatory drugs)

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TPA

________ (tissue plasminogen activator): opens blocked vessels rapidly to restore circulation before oxygen loss causes permanent damage.

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NSAIDs

________ are useful for treating mild to moderate pain, arthritis, and post- operative pain.

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Antiretroviral treatment

________ may prevent or reverse the condition in many patients.

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Pain

________ is in the brain, not in nociceptors that respond to injury.

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active CART

Highly ________ is effective in reducing the incidence of severe HAND.

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Early imaging

________ is beneficial because tumors can be identified at a lower grade.

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Caucasians

________ are more susceptible to Multiple Sclerosis than other races.

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Vaccines

________ made from the tumor with things that boost the immune system or kill tumor cells.

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Antiepileptic

________ and antidepressants are useful for treating neuropathic pain coming from injury to the nervous system.

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Secondary pathogenesis

________: damage that occurs after the initial injury.

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MS

________ can affect many other brain areas, including white matter and grey matter.

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Epidemiologists

________ are looking into tumor genetics and patients lifestyles, environments, occupations, medical histories.

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Capsaicin

________ is the pungent chemical responsible for spice in hot peppers.

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Local anesthesia

________: loss of sensation in a limited area.

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Multiple Sclerosis

________ (MS): Autoimmune disease where the immune system attacks the myelin sheath covering the axons of neurons in the Central Nervous System.

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Neural stem cells

________ can help recovery even if administered several days after the injury.

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Primary brain tumors

Tumors that begin in brain tissue but don't spread to other tissues.

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Malignant brain tumors

Harmful tumors that can originate from the brain or spread to the brain.

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Grade

The severity of a tumor.

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Gliomas

Brain and spinal cord tumors originating in and comprised of cancerous glial cells.

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Monoclonal antibodies

Antibodies produced by clones of a single cell.

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Anti-angiogenic therapy

A way to combat cancer by restricting the tumor's blood supply.

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Immunotherapy

A therapy using the body's own immune system against the tumor.

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Gene therapy

A therapy delivering bioengineered genes to tumor cells to kill them.

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Chlorotoxin

A scorpion-derived toxin that can interfere with the spread of a tumor.

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Epidemiologists

Scientists who study disease in human populations.

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Multiple Sclerosis (MS)

An autoimmune disease where the immune system attacks the myelin sheath covering the axons of neurons in the Central Nervous System.

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Lesions/plaques

Areas of disease activity appearing in multiple places in the Central Nervous System.

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White matter

Areas comprised of myelinated nerve fibers.

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Grey matter

Areas rich in neuron cell bodies and dendrites.

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Progressive MS

Ongoing nerve fiber degeneration causes the symptoms to become permanent and gradually worsen.

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AIDS (acquired immunodeficiency syndrome)

Advanced HIV infection.

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HAND

HIV associated neurocognitive disorder.

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CART (combination antiretroviral treatment)

A cocktail of 3+ drugs that are meant to work against HIV.

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Cytokines

Cell-coded immune signaling molecules.

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Peripheral neuropathy

Nerve injury in the extremities that results in the disease or dysfunction of one or more peripheral nerves.

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Secondary pathogenesis

The damage that occurs after the initial injury.

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72

Decompressive craniectomy

The removal of part of the skull to give the brain space to swell.

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73

Methylprednisolone

The only FDA-approved treatment for spinal cord injury.

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74

Local anesthesia

The loss of sensation in a limited area.

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75

Analgesia

The loss of pain sensation.

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76

Antiepileptic agents

Drugs that are used for treating epilepsy but are also used to treat neuropathic pain and fibromyalgia.

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77

Antidepressants

Drugs that are used for treating depression, chronic, and neuropathic pain.

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78

Acetaminophen

A drug that has analgesic properties but does not reduce inflammation.

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79

Nociceptors

Peripheral nerve fibers that initially respond to an injury stimulus.

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80

Seizures

Occur due to sudden, disorderly changes in interconnected brain neurons.

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81

Epilepsy

A chronic neurological disorder characterized by the occurrence of unprovoked seizures.

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Idiopathic epilepsies

Epilepsies arising from uncertain or unknown cause.

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Symptomatic epilepsies

Epilepsies with a known or presumed cause.

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Generalized epilepsy

A disorder characterized by the loss of consciousness and range of behavioral changes including convulsions and sudden changes in muscle tone

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Partial epilepsy

A disorder where the individual maintains consciousness or has altered awareness and behavioral changes.

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Electrical stimulation therapy

An implanted device delivers small bursts of electrical energy to the brain via the vagus nerve on the side of the neck.

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Stroke

Occurs when a blood vessel bringing oxygen and nutrients bursts or is clogged by a blood clot or some other particle.

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88

tPA (tissue plasminogen activator)

A molecule that opens blocked vessels rapidly to restore circulation before oxygen loss causes permanent damage.

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