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(Quiet Breathing) What is the goal of quiet breathing?
Gas exchange → CO2 (carbon dioxide) for O2 (oxygen)
(Quiet Breathing) What is alveolar pressure at baseline?
Alveolar Pressure = Atmospheric Pressure
(Quiet Breathing) What occurs during active inspiration?
Diaphragm contracts & flattens
Intercostal elevate & twist ribs
Thorax expands
Intra-pleural pressure (pressure in the lungs) decreases
Abdomen compresses
abdominal pressure increases
Further thoracic expansion
Intra-pleural pressure decreases some more
Alveolar pressure decreases
Lungs pulled by chest wall – alveoli expand
Alveoli expansion is passive
(Quiet Breathing) How does lung pressure change with decreased alveoli pressure?
lung pressure is now less than atmospheric pressure, & air enters the system
Air continues to enter until baseline pressures (alveolar = atomospheric)
(Quiet Breathing) What occurs during expiration (exhalation)?
Passive expiratory forces = relaxation pressures
Gravity
Torque
Elastic recoil
all work together to reverse actions of inspiration!
(Quiet Breathing) How do intrapleural & alveolar pressures change during expiration?
Both intrapleural pressure and alveolar pressure are greater than atmospheric pressure.
What is the gas exchange process?
CO2 for O2
exchange is via the alveolar capillaries
“dead space” – structures of no gas exchange
Walls too thick so not O2 permeable
O2 carried via Hemoglobin (Hb)
What is the process of gas exchange at alveoli?
respiration!
What is the process of gas exchange in/out of lungs?
ventilation!
(Gas Exchange Process) What is the respiratory rate for a normal adult?
12-20 breaths per minute (bpm)
(Gas Exchange Terms) Oxygen Saturation:
amount of oxygen in the blood
SpO2 = measured peripherally w/ a sensor (“pulse oximetry”)
SaO2 = measured internally in the lab thru blood
(Gas Exchange Terms) Perfusion:
amount of blood (& therefore oxygen) reaching the tissue
(Gas Exchange Terms) Hypoxemia:
Not enough O2 in the blood
(Gas Exchange Terms) Hypoxia:
Not enough O2 in the tissue
(Gas Exchange Terms) Hypercapnia:
excessive CO2 in the blood
Forced Breathing:
body has increased demand for air
during physical exertion (healthy person)
(Forced Breathing) What does forced inhalation require?
use of primary AND accessory muscles of respiration
(Forced Breathing) What does forced exhalation require?
passive expiration AND active contraction of intercostals & abdominal muscles
(Forced Breathing) What occurs to tidal volume during forced breathing?
it increases
(Forced Breathing) Respiratory rate?
stays the same or slows down
What does speech breathing require?
active inspiration AND active expiration against/through:
upper airway resistance
continuously modulating due to VF & articulator valving action
Inspiration during speech breathing:
cycle is shorter relative to expiration
When does phonation occur?
on expiration
Should speech breathing require larger inspiratory volumes?
Should not require larger inspiratory volumes—typically, if adequate breath support for quiet breathing exists, then, adequate breath support for speech exists,
– But:
Louder voice requires increased inspiratory volume above tidal volume
Longer phrases require increased inspiratory volume above tidal volume
What is tidal volume at during speech breathing?
~35-40% of vital capacity
Conversation = initiated w/ large increase in air up to ~55-60% of vital capacity
So, speech breathing really uses some amount of inspiratory reserve volume or “extra air”
~20% more than tidal volume ?
Speech breathing requires more air than regular quiet breathing (tidal breathing), because you need to produce longer and more controlled exhalations to speak in phrases or sentences.
Tidal volume (TV) is the amount of air you breathe in and out at rest.
When speaking, you typically inhale about 20% more air than tidal volume, tapping into your inspiratory reserve volume (IRV)—the “extra air” you can inhale beyond a normal breath.
Key Point:
Speech breathing uses ~20% more air than tidal breathing by drawing from inspiratory reserve volume to support longer, controlled exhalation needed for speech.
What is required to maintain adequate alveolar pressures for speech (& life)?
Balance between active inhalation, active exhalation, and passive exhalation/recoil
(Neurophysiology of Breathing) What is the role of the Brainstem Central Pattern Generator (CPG)?
maintains balanced O2 & CO2
CO2 levels are the primary drivers of ventilation regulation
What are the 2 main types of receptors for breathing?
chemoreceptors
stretch receptors
Chemoreceptors (blood-bourne):
react to the amount of a chemical in the system
Central
Peripheral
(Chemoreceptors) Central:
in the medulla (anatomically separated from the respiratory CPG); react to chemistry changes in CSF
CO2 → receptors constantly monitoring levels and adjusting ventilation as need to keep acid (H+) /base (HCO3-) balanced (respiratory homeostasis)
(Chemoreceptors) Peripheral:
CO2 receptors—in the aortic body & in the carotid bodies, constantly monitoring & adjusting to keep homeostasis, sends info to the medulla
» O2 receptors –in the aortic body and carotid bodies; while constantly monitoring, only react when levels are low.
Stretch receptors (afferent & efferent neural):
React to the amount of muscle stretch in a muscle system
Breathing—in the smooth muscle of the airway, react to expansion/deflation of the lungs and bronchi
(Blood Gases) What does respiration work with to regulate CO2 in the system (blood)?
renal function!
Respiration: CO2 exhaled
Renal: HCO3 exreted out through kidneys/bladder
What can occur if there is a problem in either respiration or metabolic renal function?
the body loses homeostasis, pH will either rise or fall depending
pH high = alkalosis
pH low = acidosis
Hyperventilation:
excessive ventilation, lungs eliminate more CO2 than is produced, so there is not enough left in the blood
→ Respiratory Alkalosis (pH high)
Hypoventilation:
inadequate ventilation, lungs don’t eliminate enough CO2 so body retains CO2
→ Respiratory Acidosis (pH low)