Cholesterol transport

Chylomicrons

Transport TG from intestines to tissues

ApoB-48

Chylomicron assembly and secretion by the intestine And rememenants

Chylomicrons

Transport TG from intestines to tissues

ApoB-48

Chylomicron assembly and secretion by the intestine And rememenants

chylomicron remnant

Left over chylomicron and cholesterol esters to liver

ApoE

VLDL , IDL

VLDL

transport TG

Liver ---> tissue

ApoB-100

LDL, VLDL

ApoC-II

activates lipoprotein lipase

HDL VLDL

Apo(a)

Lp(a)

ApoA-1

Activates LCAT and found on HDL

Cholesterol efflux ABCA1

ApoA-II

HDL

Activate hepatic lipase

IDL

• VLDL remnant

• transition between triacylglycerol and cholesterol transport

• picks up cholesteryl esters from HDL

LDL

• Cholesterol esters --> tissues

• 60% -70% cholesterol

• more sat fats = more LDL

Lp(a)

Type of LDL with extra apoa attached

Increase heart disease blood clot plaque build up

HDL

Cholesterol esters to liver

20% to 30% of cholest

lipoprotein lipase (LPL)

An enzyme that breaks down triglycerides into fatty acids.

Apo-C-11 activate

Hepatic Lipase (HL)

-A glycoprotein that catabolizes the hydrolysis of triglycerides and phospholipids

Lecithin-cholesterol acyltransferase (LCAT)

Formation of HDL

esterifes cholesterol

LRP

help liver take CM remnants

ABCA1 transporter

Move excess free cholesterol and phospholipids into plasma membrane

Removes excess cholesterol from foam cells

foam cells

Macrophages that have consumed lipid, seen in atherosclerosis pathogenesis

SR-A1 scabeher receptor a1

Help immune cell take in oxidized LDL

Athreosclerosis

hardening of the arteries

Lipids function

store energy

Transport fat soluble vitamins

Lipoproteins structure

core of triglycerides and cholesterol esters (hydrophobic)

outer- apoliproteins, phospholipid, cholesterol

bile salts

emulsify fats

Absorb fat soluble vitamins

Must abundant tauracholaye and glycocholate