BBB drugs

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5 Terms

1
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P-go substrates

  • Cyclosporine A

  • Verapamil

  • Valspodar (effective concentration are toxic)

2
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Noncompetitive inhibitors of P-gp

  • Tariquidar

  • Laniquidar

  • Zosuquidar (More specific and less side effects)

3
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Roche anti-amyloid (GANTENERUMAB)

Phase 1 clinical trial for Alzheimers

Targets ABplaques in the brain 

4
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Intrathecal drugs

  • Morhine

  • Ziconotide

  • Baclofen

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Drugs used in intranasal

  • Naloxone

  • Sumatriptan, zolmitriptan- migraine

  • Oxytocin- autism

  • Benzodiazepine- seizures

  • Insulin- memory, anxiety, mood in AD