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What did Frederick Griffith do?
He wanted to determine how bacteria were able to cause pneumonia. He set up two bacterial strains, one disease-causing and one harmless.
He then injected heat-killed versions of the disease-causing bacteria into the mice. Many mice survived. But after injecting them with a mixture of heat-killed dangerous bacteria and healthy harmless bacteria, many mice died.
The disease-causing bacteria had passed their deadly ability to the harmless strain.
What did Oswald Avery do after that?
He repeated Griffith’s work. He had a strain of heat-killed dangerous bacteria, and after treating it with enzymes that destroyed proteins, lipids, carbohydrates, and RNA found that it could still pass on its disease-causing ability. But this ability was lost the moment he treated it with enzymes that destroyed DNA.
He was the first scientist to show that DNA was the genetic factor.
What is a bacteriophage?
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