50S protein inhibitors clinc. app

macrolide

* eryth__romycin__
* azith__romycin__
* clarith__romycin__

\
belongs to _______ drug class

macrolide

* enterobacteriaceae
* pseudomonas, acinetobacter
* most anaerobes

are not susceptible to _______

false

true or false

\
macrolide has a wide coverage spectrum including gram positive, gram negative, and atypical microbes. However, most aerobes are not susceptible to Macrolides

* S.pneumoniae
* Streptococcus spp
* Staphylococci

List 3 gram positive aerobes that are susceptible to macrolide

H/ influenzae

M. catarrhalis

list the 2 gram negative aerobes that are susceptible to macrolide

* mycoplasma
* chlamydia
* legionella

list the 3 atypical microbes that are susceptible to macrolide

false

true or false

\
due to macrolide broad spectrum, it is usually used to treat pseudomonas infections

upper respiratory tract infection

what is the most common clinical uses of macrolide?

macrolide

* upper and lower respiratory tract infection
* peptic ulcers due to H.pylori
* treatment and prophylaxis of mycobacterium
* STD

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are the clinical uses of __________

clarithromycin

which of the following only comes in PO form?

\
A. erythromycin

B. clarithromycin

C. azithromycin

D. piperacillin-tazobactam

B. clarithromycin

which of the following requires renal dose adjustment in patients with poor kidney function?

\
A. erythromycin

B. clarithromycin

C. azithromycin

ALL macrocodes are renally cleared and are major inhibitors of CYP3A4

which of the following statements is FALSE?

\
A. macrolides obtain high intracellular concentrations

B. macrolides are a great choice for intracellular pathogens

C. ALL macrocodes are really cleared and are major inhibitors of CYP3A4

* __M__otility problems (NVD, abdominal pain)
* __A__rrhythmias
* __C__hanges to sense of tast
* Skin __R__eaction

list the side effects of MACRolides

bateriostatic

macrolides are __________

A. Bacteriostatic

B. Bactericidal

true

true or false

\
macrolides are alternative for patients with penicillin allergy

lyncosamides

clindamycin belongs to _______ class

lyncosamides

* excellent drug for gram positive infection
* covers MRSA (outpatient skin infection)
* inhibits toxin production in S.aureus and streptococcus
* good anaerobic coverage
* not for gram negative infection

\
are the spectrum coverage of ________

inhibition of toxin production in S.aureus and streptococcus

what is the unique feature of clindamycin?

false

true or false

\
clindamycin only covers gram NEGATIVE microbes

true

true or false

\
using clindamycin can increase the risk of B.fragilis resistance

above

clindamycin used to cover anaerobes _______ the diaphragm

* oral infection
* skin infections (MRSA)
* streptococcus toxic shock
* necrotizing fasciitis
* lower respiratory tract infection

what are the clinical uses of clindamycin? (5)

false

true or false

\
clindamycin is used for lower respiratory tract infections including community associated pneumonia and lung abscesses

clindamycin

* NVD, metallic taste
* antibiotic-associated colitis due to closridioides difficle

\
are the adverse reactions of ________

associated with Clostridioides difficile infection

which of the following is TRUE regarding Clindamycin?

\
A. drug of choice for lower intra-abdominal infections

B. Associated with Clostridioides difficile infections

C. drug of choice against any resistant gram-negative infections such as pseudomonas aeruginosa

oxazolidinones

linezolid belongs to _______ class

true

true or false

\
linezolid DOES NOT exhibit cross-resistance with other antibiotic drugs

linezolid

* gram positive aerobes (staph, MRSA, strep, enterococci, VRE)
* mycobacteria tuberculosis
* no gram negative coverage

are the coverage spectrum of _______

false

true or false

\
Linezolid is a good drug target for MRSA and VRE because it covers both gram positive and gram negative aerobes

linezolid

________ is reserved for multi-drug resistant gram positive

* hospital acquired pneumonia (reserved for MRSA)
* VRE infections
* complicated skin infection

what are the clinical uses of linezolid?

linezolid

* both PO and IV administration
* 100% bioavailability
* no dosage adjustment for hepatic or renal impairment

\
the following statements are features of _______

* bone marrow suppression
* mitochondrial toxicit
* central nervous (headache, insomnia)

what are the adverse reactions of linezolid?

at least weekly

how often should CBC be monitored when patient is on linezolid?

linezolid

which of the following interact with SSRIs, aged cheese, cured meats, and red wine?

\
A. azithromycin

B. clarithromycin

C. clindamycin

D. linezolid

A. bacteriostatic

linezolid is ______

A. bacteriostatic

B. bactericidal