FXI Inhibitors Pharmacology

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Last updated 4:07 AM on 9/14/26
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11 Terms

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hemophilia C

factor XI deficiency

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What is a benefit to inhibiting factor XI?

could protect against thrombosis without significantly increasing risk of spontaneous bleed

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categories of factor XI inhibitors

- monoclonal antibodies

- synthetic small molecules

- antisense oligonucleotides

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MOA of monoclonal antibodies

directly binds to Factor XI/XIa to inhibit Factor XI activation or activity

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monoclonal antibodie agents

- abelacimab

- osocimab

- xisomab 3G3

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MOA of synthetic small molecules

binds to Factor XIa

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synthetic small molecules agents

- asundexian

- milvexian

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MOA of asundexian

binds reversibly to the active unit of Factor XIa

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MOA of milvexian

binds to the active unit of Factor XIa

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MOA of antisense oligonucleotides

binds sequence specifically to target mRNA

-> mRNA can no longer be read

-> translation of target protein cannot occur

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antisense oligonucleotide agents

- IONIS-FXI-LRx

- fesomersen