PNN Live - HIV

Screening

ELISA

Diagnosis

Western blot

Tests after diagnosis

CD4, viral load count, genotype testing

PCP prophylaxis

CD4<200

Bactrim - if sulfa allergy, atovaquone (Mepron) or dapsone

MAC prophylaxis

CD4<50 and not fully on ART

Azithromycin 1200 mg QW or clarithromycin 500 mg BID

Toxoplasmosis prophylaxis

CD4<100 and must be seropositive

Atripla

efavirenz-emtricitabine-TDF

Zidovudine side effect

Bone marrow suppression

Complera

rilpivirine-emtricitabine-TDF

With food - supplement with vitamin D and calcium

HLA-B*5701 testing required

Abacavir

Epzicom (abacavir-lamivudine)

Trizivir (abacavir-lamivudine-zidovudine)

Triumeq (abacavir-lamivudine-dolutegravir)

-gravir

Integrase inhibitors

PEP

Truvada plus raltegravir (BID) OR dolutegravir (QD) for 28 days, start within 1-2 hours (no later than 72 hours)

Epzicom

abacavir-lamivudine

Trizivir

abacavir-lamivudine-zidovudine

Triumeq

dolutegravir-abacavir-lamivudine

Sulfa allergy

Darunavir, fosamprenavir, tipranavir

Pregnancy recommended therapy

zidovudine-lopinavir/ritonavir-lamivudine

Combivir

zidovudine-lamivudine

Retrovir

Zidovudine

Truvada

emtricitabine-TDF

NRTI class side effects

Headache, lactic acidosis, hepatic steatosis, renal

Ziagen

Abacavir

Epivir

Lamivudine

Emtriva

Emtricitabine

Viread

Tenofovir (TDF)

Vemlidy

Tenofovir (TAF)

NNRTI class side effects

Rash, hepatotoxicity

Edurant

Rilpivirine

Viramune

Nevirapine

Sustiva

Efavirenz

Intelence

Etravirine

Pifeltro

Doravirine

INSTI class side effects

GI, CNS

Isentress

Raltegravir

Biktarvy

bictegravir-emtricitabine-TAF

Genvoya

elvitegravir-cobicistat-emtricitabine-TAF

Stribild

elvitegravir-cobicistat-emtricitabine-TDF

Tivicay

Dolutegravir

Apretude

Cabotegravir IM

Vocabria

Cabotegravir PO (short term)

Medications without regards to food

All entry inhibitors

All NRTI except didanosine and TAF

NNRTI - nevirapine and doravirine

INSTI - raltegravir and dolutegravir

Medications on empty stomach

Efavirenz, fosamprenavir

Medications with food

Rilpivirine, etravirine, and ALL PI except fosamprenavir

Cabenuva

cabotegravir-rilpivirine

IM gluteal monthly or every 2 months

Refrigerated

PI class side effects

Hyperglycemia, hyperlipidemia, lipodystrophy

Kaletra

lopinavir-ritonavir

Reyataz

Atazanavir

Evotaz

atazanavir-cobicistat

Prezista

Darunavir

Prezcobix

darunavir-cobicistat

Lexiva

Fosamprenavir

Norvir

Ritonavir

Aptivus

Tipranavir

Black box intracranial bleeding

tipranavir (Aptivus)

Juluca

dolutegravir-rilpivirine

With food, separate from antacids, step down therapy

Dovato

dolutegravir-lamivudine (demi lovato)

Two drug regimen for HIV patients who have NEVER received therapy

Descovy

emtricitabine-TAF

Odefsey

rilpivirine-emtricitabine-TAF

Symtuza

darunavir-cobicistat-emtricitabine-TAF

PrEP

Truvada - DO NOT GIVE if CrCl <60

Descovy - DO NOT USE if CrCl <30

Apretude - CAN USE if CrCl <30

HIV

CD4>200

AIDS

CD4<200

CMV treatment

Ganciclovir IV - bone marrow suppression, made in vertical flow (class 2 cabinet)

Valganciclovir PO - bone marrow suppression, with food

Foscarnet IV - seizures

Sofosbuvir and amiodarone

NEVER given together, causes bradycardia

-navir

Protease inhibitors

Rukobia

Fostemsavir (gp120)

Trogarzo

Ibalizumab-uiyk (CD4 receptor blocker)

IV

Maraviroc

Selzentry (CCR5 blocker)

Tropism test used to decide if helpful

Fuzeon

Enfuvirtide (gp41)

SQ BID

NRTIs

ZALEs dT

NNRTIs

RNEED

INSTIs

RBD

PIs

LAND FIRST

SULFA ALLERGY

Off market NRTIs that cause pancreatitis and peripheral neuropathy

Stavudine (Zerit) and Didanosine (Videx)

Rilpivirine should not be given with

PPIs because of decreased absorption

Jaundice is caused by

Atazanavir