EXPH 2045: Physiology - Neuromuscular Junction

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Last updated 6:21 AM on 9/22/26
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8 Terms

1
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Step 1

Action potential travels down motor neuron

2
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Step 2

Voltage Gated Ca²+ channels open in motor end plate, Ca²+ enters neuron

3
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Step 3

Ca²+ causes synaptic vesicles with Acetylcholine to do exocytosis, Acetylcholine releases to synaptic cleft

4
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Step 4

Acetylcholine binds to ligand gated Na+ channels, Na+ flows into muscle fiber (local depolarization)

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Step 5

Action potential propogates bidirectionally

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Step 6

Action potential travels down T-tubule to sarcoplasmic reticulum

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Step 7

Ca²+ released from sarcoplasmic reticulum into sarcoplasm

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Step 8

Ca²+ binds to troponin, moves tropomyosin to reveal active site