week 14: class projects

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Psychology

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1
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what happens when older adults drive with unidentified pre-AD?
Driving skills decline lead to increased accidents when driving
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driving behaviour changes (rapidly/subtly) in pre-AD
subtly
3
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how does driving behaviour serve as a biomarker?
practical method to identify biomarkers for older persons early on
4
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adverse driving behaviours are associated with...
sleep apnea severity and age in CN older adults at risk for AD
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how can we distinguish between people who have pre-AD biomarkers and those who don't
Machine learning
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people with AD and _______ ________ had a higher risk of engaging in erratic driving behaviour
sleep apnea
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how can we measure driving behaviour?
GPS driving logging
8
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what is one question to consider when thinking abt driving and AD?
how early can driving behaviour indicate to us AD?
9
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why is it interesting to study autism and AD?
because they occur at opposite ends of the lifespan
10
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Brain plasticity in people with ASD (does/does not) protect them from cognitive decline overall
does
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people with AD have (high/low) brain plasticity. people with ASD have (high/low) brain plasticity
low, high
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what is a potential link between AD and ASD development
heavy metals
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how do heavy metals act as a potential link between AD and ASD?
blocks methylation
14
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these types of mutations could cause not only ASD but AD
Activity-dependent neuroprotective protein mutations
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4 commonalities between ASD and AD
- interaction between genetic, epigenetic, and environmental factors
- overlapping pathophysiology: processing mechanisms of amyloid precursor protein
- poor cognitive health
- anxiety and depression
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2 major signs of ASD are
anxiety and depression
17
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things to consider when thinking about ASD and AD?
What other characteristics of ASD could be a protective factor? Are there risk factors?
18
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what is down syndrome?
aka trisomy 21
- born with 3 copies of chromosome 21, known as trisomy 21
- 1/800 births are DS
- Defining physical features
- Susceptibility to infections, hearing loss, etc.
- Increased risk of AD
19
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what do DS and AD have in common?
accumulation of plaques and tangle deposits
20
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how does chromosome 21 affect AD?
carries a gene that produces one of the key proteins, amyloid protein, involved with changes in the brain associated with Alzheimer's.
- Amyloid-β is a product of the chromosome 21 gene APP
21
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what is a misconception about AD and DS?
Most never assume that a mutation in a single chromosome could lead to so many adverse outcomes
22
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commonalities between DS and AD
Cognitive decline, shorter tempers, impulsivity, and memory issues
23
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implications for understanding DS and AD
Raising awareness in both will hopefully help understand a cure for AD and helping people with DS live longer lives
24
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what is a possible intervention for DS and AD research?
Manipulating chromosomes a possible step for intervention
25
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the risk of MCI and AD is related to...
how much sleep you get
26
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sleep disturbances are observed in...
AD patients
27
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sleep disturbances often appear at what point in the disease?
may appear early in disease progression
28
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4 reasons why sleep is so important
- Supports brain function
- Memory consolidation
- Promotes brain metabolic clearance
- Increases chromosome dynamicse
29
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effects of sleep deprivation
- Fatigue, poor decision making, and greater risks of accident
- Decreases temporal lobe activity
- Poor concentration, emotional instability, immune dysfunction
- Increased sensitivity to pain
30
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how must we sleep in order to improve QoL?
need to have a balanced sleep cycle
31
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3 common sleep disorders include
Sleep apnea
Insomnia
Restless leg syndrome
32
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sleep disorders are significantly associated with __________ but not ______________
increased risk of MCI, but not clinical conversion
33
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(1) or (2) significantly increased risk of MCI. (3) predicted progression to AD. These findings are related to (4)
(1) insomnia (2) sleep apnea (3) sleep apnea (4) hypoxia
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sleep disorders may affect levels of ____________
beta-amyloid and tau
35
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sleep-wake cycles and circadian rhythm help regulate
beta amyloid levels in the brain
36
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beta amyloid in cerebrospinal fluid is (highest/lowest) when awake and (highest/lowest) when asleep
highest, lowest
37
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Sleep deprivation increases _________________ in brain in ISF and CSF in the brain
tau levels
38
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Tau levels in _____ increased by more than 50% during sleep deprivation
CSF
39
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things to consider when studying sleep and AD
effects based on sex, depression, comorbidities, and APOE e4
40
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what is MBI?
late-life psychiatric symptoms not described by other psychiatric disorders
41
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MBI is another _____-________ ________ for NDDs. This means that...
at-risk state. Can increase risk for NDD
42
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MBI is an early indicator of...
dementia
43
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What does MBI cover that MCI does not?
behavioural and psychiatric symptoms
44
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who is dr. ismail?
clinical neuropsychiatrist studying MBI and AD in Calgary
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what is ISTAART?
researchers and clinicians who work to further AD research
46
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5 domains of MBI
- Decreases motivation: apathy and indifference
- Affective dysregulation: depression, anxiety, elation, euphoria
- Impulse decontrol: agitation, disinhibition
- Social inappropriateness
- Abnormal perception or thought content: delusions and hallucinations
47
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conditions for MBI diagnosis
Symptoms must be de novo, diagnosed later in life (>50) and experienced for 6 months or more
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how do we measure MBI?
MBI-C: - 34-item diagnostic checklist done by patient, informants, and physicians
- developed by dr. ismail
- covers all 5 domains
- yes/no questions and likert scale
49
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how must we consider MBI for AD diagnosis?
considered alone and with other MCI symptoms
50
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Of the people who progressed to dementia, _______% had only SCD+, whereas _____% had both MBI and SCD+ symptoms
16.5%, 30.9%
51
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what is the most common MBI domain?
Affective Dysregulation
52
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what is affective dysregulation in MBI?
Depression, anxiety, elation, euphoria
53
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MBI-affective dysregulation has a higher incidence in...
black participants and APOEe4 carriers
54
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some key areas that still need to be developed re: MBI
having an agreed-upon definition
- standardization
55
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what is dance therapy?
Psychotherapeutic use of movement to promote emotional, social, cognitive, and physical integration
56
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dance therapy is (the same as/different from) choreography done in regular dance classes
different from
57
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why is movement used in dance therapy so beneficial?
people can express themselves through movement, opportunities for socialization, building community, developing vitality
58
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can anyone teach dance therapy?
no. therapists are dancers with professional psychology knowledge
59
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3 parts of dance therapy
- Warm-up part: clinicians will let clients dance and move freely to the rhythm and beat
- Development: clients will get their movements deeper and interact with others
- Closure: clients say goodbye and refocus on themselves
60
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4 areas that dance movement therapy can assist with
- Physical issues: hypertension and cardiovascular disease
- Mental health (depression, anxiety)
- Cognitive issues (communication)
- Social issues (social interaction)
61
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DMT can directly influence...
memory recall in people with late-stage AD
62
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limitations of current research on dance therapy and AD
- Participant population pretty small
- Assessments not included
- LONG effects of DMT on memory should be studied
63
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future directions for dance therapy and AD
- LONG studies
- Can DMT help with other symptoms?
64
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an experiment on DMT and AD revealed that...
Participants at risk of AD showed more organized speech and acute memory recall
65
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DMT can directly influence memory recall in people with (early/late)-stage AD. However, these findings are acute/long-term
late, acute
66
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what is still unknown about DMT and AD?
the exact cause/mechanism underlying memory recall
67
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what is caffeine?
drug/neuro stimulant that is found in many consumer substances like coffee, tea, energy drinks, medication, and chocolate
68
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how does caffeine work in the body?
travels in bloodstream and across BBB and acts as a stimulant
69
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caffeine is a possible (risk/protection) factor
protection
70
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the current evidence regarding caffeine and AD is quite (consistent/contradictory)
contraidictory
71
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what did the CAIDE study find re: mid-life coffee/tea consumption and dementia?
- Moderate coffee drinkers in midlife had 62-64% decrease in risk when compared to low coffee consumers
- Tea drinking mostly uncommon and did not show a relation to later risk of AD
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what did the CAIDE study find re: caffeine consumption, APOE e4, and sex?
e4 carriers and men showed more prominent results
73
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what are the proposed mechanisms underlying caffeine as a protective factor of AD?
- Caffeine is a nonselective A1 and A2 adenosine receptor agent
- Effect of coffee may be due to antioxidant capacity in circulating blood
- Decrease risk of type 2 diabetes – coffee abundant with magnesium, increase in insulin sensitivity
74
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What did Maia and de Mendonca (2002) find re: caffeine and AD?
Caffeine exposure during 20-year period significantly inversely related to AD
- Caffeine intake associated with lower risk of AD, independent from other possible confounding variables
75
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Maia and de Mendonca (2002) believe that:
an unknown genetic/environmental factor might favor the inclination to consume coffee
76
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what is the coffee vs. caffeine bias issue?
there are substances in coffee, not just caffeine. not sure if caffeine specifically is an RF
77
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what did Schreiner & Popescu find re: caffeine bias and AD?
- Caffeine PF effect directly related to beta amyloid
- Destabilized the beta amyloid structure through multiple mechanisms, potential inhibitory of acetylcholinesterase
78
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what did Schreiner & Popescu find in their animal model trial?
positive effects: caffeine administration did have a neuroprotection effect: improved spatial learning ability and memory capacity, or a reduction in a neuroinflammation and oxidative stress
79
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what did Schreiner & Popescu find in their human subject trial?
same as in their animal model study: numerous positive effects
80
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what is the most frequent hypothesis for the pathophysiological basis of caffeine effects in AD?
reduction in oxidative stress and neuroinflammation
81
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what else needs to be done to better understand AD and caffeine?
- clinical trials
- long-term administration
- replication trials
82
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caffeine may play a direct role in destabilizing...
the beta-amyloid peptide
83
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how can bilingualism be a protective factor?
contributes to cognitive reserve
84
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how was bilingualism and AD studied?
assessed metabolic activity combined and connectivity in bilingual and monolingual individuals with AD using a PET scan
85
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what was found in the correlation study re: bilingualism and AD?
Bilinguals with AD compensate better for loss of brain structure and function according to metabolic activity analysis
86
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bilingual speakers manifest symptoms of AD (earlier/later) than monolinguals
later
87
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an (increase/decrease) in white matter densities was found in bilinguals compared to monolinguals. This means that...
increase; using executive function to control two language systems vs. one result in plastic changes in the brain
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effects of speaking 2 languages is more powerful than both these two factors in protecting one against AD:
age, education
89
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T/F: loneliness affects everyone the same way
false
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is loneliness biologically programmed?
at the moment it is believed to be biologically programmed
91
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depression is a (modifiable/nonmodifiable) risk factor
modifiable
92
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there is a correlation between loneliness and...
depression
93
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depression can reduce onset of dementia by ___%
5%
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what did Wilson et al. (2007) find in their LONG study re: loneliness and AD?
- Those with AD had higher levels of loneliness
- Social isolation have been associated with dementia/cognitive decline in older people
- Number of people with dementia was more than doubled in lonely people
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what did Salinas et al (2002) find re: loneliness and dementia?
LONG study found that lonely adults who are under age 80 were 3x more likely to get dementia even without e4
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Salinas et al (2020) found that lonely adults have these 3 features:
- Poorer executive function
- Lower total cerebral volume
- Loneliness is major risk factor
97
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implications of understanding loneliness and dementia
need to implement programs to help older adults not lose and create social ties (PFs)
98
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how might AD cause crime?
NDDs can cause impairments of many neural processes and pathways related to judgment sexual behaviour, violence, and self awareness
99
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in the study exploring FTD and criminal behaviour, it was found that:
only 7.7% of patients displayed criminal behaviour
- 2% of AD patients exhibited criminal behaviours as a first presentation compared to 14% of FTD and 7.8% PPA
100
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AD patients were the least likely to commit crimes, but the crimes were also...
less severe in nature