Vasoactive Molecules (Lipids)

Arise from the conversion of arachidonic acid under the influence of cyclooxeganeses (COX 1 and COX 2).

Arise from the conversion of arachidonic acid under the influence of cyclooxeganeses (COX 1 and COX 2).

Four Proinflammatory Prostaglandins1. Prostaglandin E2➢ When there is an increase of the PG in tissues, it gradually inhibits 5-lipooxygenase which eventually suppresses inflammation.2. Prostaglandin F23. Thromboxanes - TxA2, PGA2 found in platelets4. Prostacyclins (PGI2) - found in vascular endothelial cells

When there is an increase of the PG in tissues, it gradually inhibits 5-lipooxygenase which eventually suppresses inflammation.

When there is an increase of the PG in tissues, it gradually inhibits 5-lipooxygenase which eventually suppresses inflammation.

TxA2, PGA2 found in platelets

TxA2, PGA2 found in platelets

found in vascular endothelial cells

found in vascular endothelial cells

They can also be anti-inflammatory.

As neutrophils enter inflammatory sites, they use 15-lipooxygenase to produce lipoxins from arachidonic acid. The oxidized eicosanoid binds cellular receptors and inhibits neutrophil migration. Thus, there is a gradual switch in production from proinflammatory leukotrienes to anti-inflammatory lipoxins.

As neutrophils enter inflammatory sites, they use 15-lipooxygenase to produce lipoxins from arachidonic acid. The oxidized eicosanoid binds cellular receptors and inhibits neutrophil migration. Thus, there is a gradual switch in production from proinflammatory leukotrienes to anti-inflammatory lipoxins.

As neutrophils enter inflammatory sites, they use 15-lipooxygenase to produce lipoxins from arachidonic acid. The oxidized eicosanoid binds cellular receptors and inhibits neutrophil migration. Thus, there is a gradual switch in production from proinflammatory leukotrienes to anti-inflammatory lipoxins.