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Independent Variable
The variable that is measured or observed
Dependent Variable
The variable that is measured or observed
Control Group
The group that does not receive the treatment and is used for comparison
Experimental Group
The group receiving the treatment being tested
Constants
Factors kept the same for every group
Random Sampling
Choosing participants randomly to reduce bias
Bias
Anything that unfairly influences the results
Placebo
A fake treatment used to compare against the real treatment
What makes a good experiment?
one independent variable, one dependent variable, large sample size, random selection, control group, repeated trials
What should I do if I don’t know the answer?
Eliminate the wrong answers, look for scientific vocabulary, choose the most complete answer, avoid absolute words like ALWAYS or NEVER unless clearly true
Gram (g)
Measure mass : paperclip = 1 gram
Kilogram (kg)
Measures large masses : 1kg = 1000g
Meter (m)
measures length
Millimeter (mm)
very small length
Centimeter (cm)
small length : 100cm = 1m
Liter (L)
measures liquid volume
Millimeter (mL)
small liquid volume: 1000mL = 1L
Celsius (C)
measures temperature
Levels of Organization (smallest < largest)
Atom = Molecule = Macromolecule = Organelle = Cell = Tissue = Organ = Organ System = Organism
Carbohydrates
Function: quick energy
Monomer: Monosaccharide
Polymer: Polysaccharide
Examples: Glucose, Starch, Glycogen
Proteins
Function: Structure, Enzymes, Transport
Monomer: Amino Acid
Examples: Hemoglobin, Enzymes, Keratin
Lipids
Function: Long-term energy, Cell membranes, Hormones
Building Blocks: Glycerol + fatty acids
Examples: Fats, Oils, Cholesterol
Nucleic Acids
Function: Store genetic information
Monomer: Nucleotide
Examples: DNA and RNA
Nucleus
Stores DNA
Ribosome
Makes proteins
Rough ER
Modifies proteins
Smooth ER
Makes lipids and detoxifies
Golgi apparatus
Packages and ships proteins
Mitochondria
Produces ATP (energy)
Lysosome
Digests waste
Vacuole
Stores water and nutrients
Chloroplasts
Photosynthesis (Plants only)
Cell Wall
Support and protection (Plants only)
Transcription
DNA —> mRNA , Occurs in the nucleus
Translation
mRNA —-> Protein, occurs at ribosomes
Codon
Three mRNA bases coding for one amino acid
Anticodon
Three tRNA bases matching a codon
Silent Mutation
No amino acid changes
Missense Mutation
One amino acid changes
Nonsense Mutation
Creates a stop codon, protein is shortened
Frameshift Mutation
Insertions/deletions shift the reading frame, usually the most harmful
B Cells
Produce antibodies
T Helper Cells
Activate other immune cells
Cytotoxic T Cells
Kill infected cells
Macrophages
Eat pathogens, Present antigens
Neutrophils
First responders, eat bacteria
Transmissible Disease
Can spread between people: Examples = Influenza, COVID, Tuberculosis
Nontransmissible Disease
Cannot spread: Examples = Diabetes, Cancer, Hypertension
Virus
Treated with antivirals (not antibiotics): Examples = Acyclovir, Oseltamivir, Remdesivir
Bacteria
Usually treated with antibiotics: Examples = Amoxicillin, Azithromycin, Ciprofloxacin
Fungus
Treated with antifungal medications
Protozoa
Treated with antiparasitic medications
Plasma
Liquid portion carrying nutrients and hormones
Red Blood Cells
Carry oxygen using hemoglobin
White Blood Cells
Fight infection
Platelets
Help blood clot
Blood Flow Path
Body = Vena Cava = Right Atrium = Right Ventricle = Pulmonary Arteries = Lungs = Pulmonary Veins = Left Atrium = Left Ventricle = Aorta = Body
Main Job of Kidneys
filter blood, remove wastes, balance water, balance electrolytes, regulate blood pressure
Nephron
functional unit of the kidney
glomerulus
filters blood
Loop of Henle
concentrates urine
Diffusion
High—> Low concentration, No energy
Osmosis
Water moves across a membrane toward higher solute concentration: No energy
Active Transport
Low —→High concentration, Requires ATP
Passive Transport
High —> Low Concentration, No ATP
Amylase
Breaks down carbohydrates
Pepsin
Breaks down proteins
Lipase
Breaks down fats
Depolarization
Voltage-gated Na+ channels open; Na+ enters, making the inside of the neuron more positive
Repolarization
Voltage-gated K+ channels open; K+ leaves the cell, returning the membrane toward its resting potential
Resting Potential
About -70 mV, maintained by the sodium-potassium pump
Actin
Thin filament
Myosin
Thick filament, forms cross-brides with actin
Calcium (Ca2+)
Binds troponin, moving tropomyosin so myosin can bind actin
ATP
Releases myosin from actin and powers muscle contraction
FSH
Stimulates follicle development in the ovary
LH
Triggers ovulations
Estrogen
Thickens the uterine lining
Progesterone
Maintains the uterine lining for pregnancy
hCG
Maintains the corpus luteum during early pregnancy
Polar Molecules
Have unequal charges distribution: examples = water, ammonia dissolve other polar substances
Nonpolar Molecules
No charge end s: Examples = Oil, Fat, Wax dissolve other nonpolar substances
Rule for Dissolving
Like dissolves Like = polar dissolves polar = nonpolar dissolves nonpolar
Acid
High H+ Concentration , pH below 7
Base
High OH- concentration pH above 7
Neutral
pH = 7
Every 1 pH unit represents what change?
A tenfold (10*) change in H+ concentration
Blood Buffer
The bicarbonate buffer system helps maintain blood pH around 7.35-7.45
Catalyst
Speeds up a chemical reaction without being consumed
Enzyme
A biological catalyst that lowers activation energy
Le Charlier’s Principle
If a system at equilibrium is disturbed (by changing concentration, temperature, or pressure), it shifts in the direction that opposes the change to restore equlibrium
Brain
Controls and coordinates the body, processes sensory information, regulates thoughts, memory, and emotions, maintain homeostasis through the hypothalamus
Heart
Pumps blood throughout the body, sends deoxygenated blood to the lungs, sends oxygenated blood to the body, maintains blood pressure
Lungs
Exchange oxygen and carbon dioxide, help regulate blood pH by removing CO2, Oxygenate blood, remove carbon dioxide waste
Liver
Produces bile for fat digestion, detoxifies drugs and toxins, stores glycogen, vitamins, and iron, processes nutrients and makes blood proteins
Gallbladder
Stores bile made by the liver, concentrate bile, releases bile into the small intestine to digest fats
Stomach
Stores food, begins protein digestion with pepsin, mixes food with hydrochloric acid, form chyme before food enters the small intestine
Small Intestine
Completes most chemical digestion, absorbs most nutrients, receives bile from the gallbladder, receives digestive enzymes from the pancreas
Large intestine (colon)
absorbs water and electrolytes, forms and stores feces, houses bacteria that produce vitamins (such as vitamin K)
Pancreas
Produces digestive enzymes for carbohydrates, proteins, and fats, regulates blood glucose levels, secretes the hormone insulin to lower blood sugar, secretes the hormone glucagon to raise blood sugar