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arteries carry blood away from heart and divide into smaller vessels called
arterioles
what do arterioles branch into
capillaries
what happens at the capillary level
there is an exchange of nutrients, wastes, and gasses between blood and interstitial fluid
capillaries join together to form what?
venules
what do venules merge into?
veins that carry blood back to the heart
what happens in systemic circulation?
arteries carry oxygen rich blood to the body tissues and veins return oxygen poor blood back to the heart for pulmonary circulation
what happens in pulmonary circulation?
arteries carry oxygen poor blood from the right ventricle to the lungs where gas exchange occurs and veins return oxygen rich blood to the left atrium
how many layers do arterial walls have?
tunica intima, tunica media, and tunica externa (3)
what is the tunica externa made of and its function?
elastic and collagen fibers that provide support and protection
what is the tunica media made of and its function?
middle thickest layer and contains elastic fibers and smooth muscle fibers that encircle the diameter of the vessel and allows the vessel to be stretched and return to original shape
how is the tunica media controlled?
by the sympathetic nervous system regulating the diameter of the vessel by vasoconstriction or vasodilation through smooth muscle fibers
what is the tunica intima made of and its function?
contains endothelium (simple squamous) lines the lumen of blood vessels to form a barrier promoting blood flow, a basement membrane, and elastic tissue
what happens if there is damage to the endothelium?
causes platelets to stick to blood vessel walls and form plaques that narrow the linen and impede blood flow
what are elastic arteries?
large diameter arteries that have more elastic fibers in the tunica media than other arteries and they stretch under great pressure when blood is pumped into them during systole
what happens to elastic arteries during diastole?
elastic fibers recoil to continue blood flow
what are muscular arteries?
small than elastic arteries and contains more smooth muscle in their tunica media to distribute blood to different areas of the body through vasoconstriction and dilation
what do muscular arteries branch into?
arterioles and then capillaries branch from there
what are the characteristics of an arterioles?
tunica media containing mainly smooth muscles and few elastic fiber
what do arterioles control?
control blood flow into capillaries and play a large role in controlling blood pressure
blood flows from capillaries into venules that drain where?
into the veins
what 3 layers do the veins contain? and what is the thickest layer?
tunica intima, tunica media, and tunica externa (tunica externa being the thickest)
what does the arteries contain that the veins do not in their structure?
external elastic lamina and internal elastic lamina
muscular activity squeezes the veins and pushes blood toward the heart while venous valves do what?
prevents the backflow of blood in limbs
folds of the tunica intima with cusp like structures create what in the venous structure?
venous valves
what does a faulty or incompetent venous valve do?
allows back flow of blood which results in pooling of blood in the veins (varicose veins)
what vessel has the smallest diameter and thinnest walls?
capillaries
what is the structure of capillary walls?
endothelium and supported by a basement membrane and a very small lumen
fusion of plasma membranes is adjacent cells
tight junction
spaces between cells
intercellular clefts
pores in plasma membrane covered by diaphragm
fenestrations
which 2 substances are allowed to cross capillary walls with tight junctions between cells?
lipid soluble or membrane carriers (also intercellular clefts, fenestrations, and vesicles)
molecules can be transported across capillary walls by vesicles called
transcytosis
what is another word for blood pressure?
hydrostatic pressure
hydrostatic pressure at the arterial end of the capillaries causes what to happen?
plasma to be filtered across the capillary wall into the interstitial fluid
what does a filtered plasma contain and what is it then become?
nutrients, hormones, and other substances becomes interstitial fluid once it leaves the capillaries and enters the space around tissue cells
blood osmotic pressure draws what substance into the venous end of capillaries?
interstitial fluid
after interstitial fluid is brought into the venous ends of capillaries what does it bring into the blood?
fluid, metabolic waste, hormone, and other substances
what is blood pressure?
the pressure exerted by blood against blood vessel walls
where is blood pressure highest?
in the aorta and large elastic arteries until arteries branch and blood travels away from the heart which causes decrease in pressure
what vessel does blood pressure drop significantly in?
the arterioles and steadily decreases through capillaries, venules, and veins and then drops to 0 in the right atrium
what is the blood pressure gradient?
difference in blood pressure between 2 areas of circulatory system
blood pressure gradient between the aorta and right atrium causes blood to flow through…
systemic circulation
blood pressure gradient between pulmonary trunk and left atrium causes to flow through…
pulmonary circulation
within the arterioles, little to no fluctuations in blood pressure between what and what are observed in capillaries or venous vessels?
systole and diastole
blood pressure gradient between veins and right atrium is which makes it difficult for what to happen?
for venous blood flow to overcome the force of gravity causing blood to pool in large veins of the limbs
why is the bp cuff inflated to a pressure greater than the systolic pressure?
it puts pressure on the arteries, flattens it, and stops the blood flow in the artery
what happens after you inflate the bp cuff beyond normal systolic pressure?
pressure in the cuff is slowly released by opening a valve (where blood pressure is greater than the pressure in the cuff, the artery opens and blood flow returns)
where is the stethoscope placed to hear blood flow into bp?
over brachial artery
what does the examiner listen for?
turbulent flow of blood until returning to normal
what is the korotkoff sound?
noise heard during measurement of bp
why is blood pressure important?
ensures adequate blood flow to the body tissue
what happens if blood pressure is too low?
tissue perfusion may not be sufficient enough to provide cells with oxygen and nutrients (especially brain neurons and metabolic wastes)
what happens if blood pressure is too high?
can cause damage to capillaries and endothelial lining of blood vessels
what can eye exams detect?
early hypertension through damaged retinal vessels
during exercise what increases to provide adequate tissue perfusion (blood flow to tissue)
cardiac output
increase in stroke volume during exercise put more pressure on blood vessel walls which causes
arterial systolic blood pressure to increase
what is peripheral resistance?
resistance or friction blood experiences as it flows through vessels
what happens to blood pressure during aerobic exercise and why?
diastolic blood pressure stays the same or decreases slightly due to vasodilation bc widened blood vessels allow blood to flow easier
what happens to blood pressure during resistance training (weight lifting) and why?
diastolic pressure increases due to vasoconstriction (skeletal muscles contract strongly causing squeezing or compression on the arteries)
what does map stand for? and what does it tell us?
mean arterial blood pressure (in one heartbeat) tells us the average force pushing blood through arteries
why is map important
it tells us if there is enough tissue perfusion
when does MAP increase?
when cardiac output increases and when resistance to blood flow increases
how does vasodilation affect map
decreases resistance and lowers bp
how does vasoconstriction affect map
it increases resistance and increases bp