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Biology
the study of life
Big Bang
13.8 billion yrs ago, an explosion occurred and all matter came to be
stellar fusion
gravity forms stars
supernovas and cosmic collisions
create heavier elements
6 Major components to life
all living things maintain high organization
acquire/use materials and energy
sense and respond to stimuli
growth/development
reproduce
evolve
all living things maintain high organization
all living things are made of cells
plasma membranes
keep bad things out and good things in
compartmentalization
all cells have boundaries
structure vs. function
structure: shape of something
function: what it does
acquire/use materials and energy
metabolism: sum of all chemical activity taking place in an organism (break down nutrients)
regulation
internal constancy
equilibrium
equal amounts on sides of barrier (equal in/equal out)
homeostasis
constant internal environment, essential to life, non-stop chemical replacement
autopoiesis
organisms self make the components necessary to maintain itself
respond to stimuli
all organisms perceive and exhibit behavior in response to stimuli
Behavior can be
instinctive: present in a living thing from birth’
learned: resulting from experience ex: photo trophism: growing towards the sun
growth and development
development: when a growing organism becomes more complex
reproduce
asexually: dividing in half (1 parent)
sexually: producing seeds (2 parents)
DNA and genes
DNA: chemical material of genes
Genes: units of inheritance that transmit info from parent to offspring, bases include Adenine, Thymine, Cytosine, Guanine
evolution
all organisms are related by common ancestry and have changed over time, Charles Darwin and Alfred Russel Wallace
homeobox genes
specific to body planning
natural selection
individuals possess traits that help them survive and reproduce and can result in adaptations
adaptations
changes in structure, physiology, or behaviors that aid in survival and reproductive success
Last Universal Common Ancestor (LUCA)
first organism
Taxonomy
classifying organisms into smaller groups of relatedness
phylogeny
study of evolutionary relationships with genetic similarities as primary way of sorting
bacteria and archaea
prokaryotic (simple, smaller, no nucleus)
eukarya
eukaryotic (complex, larger, multicellular life, nucleus)
scientific theory
accepted as facts, start as hypothesis but growing evidence
scientific law
mathematically predictable, NOT evolution
life
life formed before free-oxygen was available, earth, prokaryotic, eukaryotic, multicellular
earth
took 1.5 billion years for life to start metabolizing and reproducing after it formed
many compounds in abundance but no free oxygen
earth’s sources of energy
lightning, volcanic activity, radiation
momentum in life
organic molecules synthesized into macromolecules that interacted, processes became more complex
outdated idea
believed new species sprang into being spontaneously from nonliving matter
Francesco Redi (1668)
disproved maggots spontaneously form on meat
Pasteur and Tyndall (1800s)
disproved microorganisms grow in sterile broth
primordial soup theory (Oparin and Haldone)
life began from organic molecules formed near Earth’s surface/pond/ocean
Oparin and Haldone
independently proposed that organic molecules could form basic materials on earth, some compounds accumulated more which made a supply of preobiotics
prebiotics
organic compounds essential to life, big step in evolution of matter towards life
Miller-Urrey Experiment
tested soup theory by mixing gases and shocking them with electric shocks. Produced amino acids, sugars, lipids, nucleic acid parts, showing theory is possible. Did NOT produce nucleotides
issues wirh soup theory
dilute, exposed
Iron-Sulfer World Hypothesis (Primordial Pizza)
Gunter Wachterhauser. prebiotics were developed on clay surfaces near hydrothermal vents of the seafloor. Larger, complex compounds formed (RNA)
Iron-Sulfer World Hypothesis (Primordial Pizza)
thermal energy, Iron and Sulfer move electrons around catalyzing reactions, beginning of autotrophic metabolism and RNA
Ridge smokers
silts form compartments and biological molecules accumulate in cell sized enclosures, prebiotics are found here
RNA
energetically easier to make, breaks down faster than DNA, can catalyze chemical reactions, likely first self-replicating molecule, almost identical to DNA structurally.
DNA
replication requires large complex enzymes, requires lots of energy, instructions for building enzymes are coded in DNA
Ribozymes (Thomas Cech and Sidney Altman)
RNA molecule that catalyzes metabolic reactions, cut and make RNAs, splice RNA fragments together, attaches amino acids to proteins
vesicle
simple hollow spheres composed of lipids and proteins, precursors to cells, formed by agitating water that contains lipids and proteins
protocell
structurally similar to a cell but not alive, vesicle with more complex insides
autotroph
synthesizes their own molecules using an external energy source (sunlight)
heterotroph
obtain the molecules needed from environment (humans)
anaerobic
dont use oxygen in their metabolic process
aerobic
uses oxygen in their metabolic process
matter
anything that occupies space and mass, life is composed of matter
chemical composition of body
25 elements are essential to people, main ones are Hydrogen, Carbon, Oxygen, Nitrogen
trace elements
required in only very small amounts
atom
smallest unit of matter
element
consists of a single kind of atom (92)
nucleus
contains protons and neutrons
electrons
negative, attracted to protons, the more electrons the more shells
atomic number
number of protons
atomic mass
how much matter it contains, protons + neutrons
isotopes
element with 2 or more atomic forms (# of nuetrons vary)
radioisotopes
break down and emit radiation
molecules
2 or more atoms linked together
compound
type of molecule with 2 or more elements combined in a fixed ratio (NaCl, glucose, water)
ionic bonds
transfer electrons, formed between oppositely charged ions, weak (NaCl)
ions
atoms that have lost or gained electrons and become electrically charged
covalent bond
two atoms share pairs of electrons, strongest, hold atoms together in a molecule (water)
polar molecule
one with an uneven distribution of charge
hydrogen bond
polarity of water molecules, results in weak electrical attractions to other water molecules, BETWEEN water molecules
cohesion
water molecules stick together as a result of hydrogen bonding, between molecules NOT within molecules
water moderates temp
water resists temp change, Earth’s water supply enables temps on planet to stay within limits that permit life by storing heat from sun and releasing it during cooler periods
regulates internal temp
water helps regulate constant temp inside cells
evaporative cooling
a substance evaporates and the surface of the liquid remaining cools down (sweat, panting)
ice floating
ice floats because it is less dense than water because the space between the molecules expands forming ice. acts as an insulating blanket over water allowing life to persist under the ice
solvent
substance that dissolves another compound
solute
compound that gets dissolved
aqueous solution
water and dissolved solute
acid
chemical compound that releases hydrogen to a solution (stomach acid)
base
a compound that accepts hydrogen and removes them from solution (bleach)
ph scale
measure of the Hydrogen ion concentration in a solution, 0(acidic)-14(basic)
physiological ph
7.4, ph affects chemical reactions
instability in ph
instability for metabolism, DNA synthesis, synaptic firing, heart beating, exhaling CO2
Alkalosis
increase in physiologic ph
causes: excessive sweating or vomiting, poor oxygenation
acidosis
decrease in physiologic ph
causes: lung and kidney disease
hydrophilic substances
interact with water readily, polar molecules
hydrophobic substances
dont interact readily with water, non-polar molecules, important in membrane formation in cells (oil)