11 - SEDIMENTATION of SUSPENSION

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12 Terms

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SUSPENSION

Pharmaceutical suspension is a dispersion in which finely divided drug particles are distributed throughout vehicle (dispersed medium) in whichdrugsparinglysoluble.

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SUSPENSION

A pharmaceutical suspension is defined as a coarse dispersion containing finely divided insoluble particles suspended in a liquid medium.

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SETTLLING SUSPENSION

One aspect of physical stability in pharmaceutical suspensions is concerned with keeping the particles uniformly distributed throughout the dispersion

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DEFLOCCULATED

Particles exist in suspension as separate entities

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DEFLOCCULATED

Rate of sedimentation is slow, as each particle settles separately and particle size is minimal

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DEFLOCCULATED

A sediment is formed slowly

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FLUCCULATED

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NON- FLOCCULATED

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FLOCCULATED

Particles form loose aggregates

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FLOCCULATED

Rate of sedimentation is high, as particles settle as a floc, whic h is a collection of particles.

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FLOCCULATED

A sediment is formed rapidly

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FLOCCULATED

The sediment is packed loosely and possesses a scaffold-like structure