BB Complement Lectin Pathway

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Last updated 1:49 AM on 9/22/26
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14 Terms

1
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What is the trigger for the Lectin Pathway?

Mannose binding to Microbe

Mannose/Microbe Complex

2
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What binds to Mannose after the Mannose/Microbe complex is detected?

MBL

3
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What binds after MBL binds to the Mannose/Microbe complex?

MASP-2

Activation of MASP-2 once it binds to MBL

4
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What two complements get cleaved by the Activated MASP-2?

C4 and C2

5
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What are C4 and C2 split into?

C4a & C4b — C2a & C2b

6
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What makes the C3 convertase in the Lectin Pathway?

C4bC2a

7
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What does C4bC2a do?

Cleave C3 into C3a & C3b

8
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What is C3a best at?

Best at INFLAMMATION

9
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What is C3b best at?

Best OPSONIZATION

the best TAG

10
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What makes the C5 convertase?

C4bC2aC3b

11
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What does C4bC2aC3b then do?

Cleaves C5 into C5a & C5b

12
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What is C5a best at?

Activating/ RECRUITING IMMUNE CELLS

13
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What does C5b do?

C5b BINDS to the Microbe, followed by 6,7,8,9,9,9,9

MAC COMPLEX


14
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What makes up the MAC Complex?

C5b,C6,C7,C8,C9 9 9 9 9 9 9 LYSIS