HCV Dr. Martin

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49 Terms

1
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Can you use SOF/VEL (Epclusa) in decompensated cirrhosis?

Yes

2
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Can you use G/P (Mavyret) in decompensated cirrhosis?

No

3
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Can you use SOF/VEL/VOX (Vosevi) in decompensated cirrhosis?

No

4
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Can you use EBR/GZR in decompensated cirrhosis?

No

5
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Can you use LDV/SOF (Harvoni) in decompensated cirrhosis?

Yes

6
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What are the HCV Pre-treatment labs?

  • Confirm HCV infections

  • HIV status

  • HBV status

  • Assess renal function

  • Assess INR

  • Check hepatic function panel (AST, ALT)

7
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GT for LDV/SOF

1,4-6

8
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GT for EBR/GZR

1,4

9
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GT for SOD/VEL

1-6

10
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GT for SOF/VEL/VOX

1-6

11
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GT for G/P

1-6

12
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Is LDV/SOF used in CKD, ESRD?

Yes

13
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Is EBR/GZR used in CKD, ESRD?

Yes

14
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Is SOF/VEL used in CKD, ESRD?

Yes

15
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Is G/P used in CKD, ESRD?

Yes

16
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Daily DAA pill burden of LDV/SOF

1

17
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Daily DAA pill burden of EBR/GZR

1

18
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Daily DAA pill burden of SOF/VEL

1

19
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Daily DAA pill burden of SOF/VEL/VOX

1

20
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Daily DAA pill burden of G/P

3

21
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Do you take with or without food: LDV/SOF

+-

22
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Do you take with or without food: EBR/GZR

+-

23
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Do you take with or without food: SOF/VEL

+-

24
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Do you take with or without food: SOF/VEL/VOX

With

25
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Do you take with or without food: G/P

With

26
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Length of therapy of LDV/SOF

8-12 weeks

27
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Length of therapy of EBR/GZR

12-16 weeks

28
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Length of therapy of SOF/VEL

12 weeks

29
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Length of therapy of SOF/VEL/VOX

12 weeks

30
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Length of therapy of G/P

8 weeks

31
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ADRs of LDV/SOF

fatigue, HA

32
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ADRs of EBR/GZR

fatigue, HA, nausea

33
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ADRs of SOF/VEL

fatigue, HA

34
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ADRs of SOL/VEL/VOX

fatigue, HA, nausea, diarrhea

35
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ADRs of G/P

Fatigue, HA

36
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DDIs for LDV

  • Needs acidic stomach for absorption

  • Caution with antacids, H2RAs, PPI

37
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DDIs for SOF

  • Substrate of P-gp and BCRP

  • Drug interactions possible with P-gp inhibitors/inducers

38
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DDIs for EBR

  • Metabolized by CYP3A4

  • Substrate of P-gp

39
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DDIs of GZR

  • Weak CYP3A4 inhibitor

  • Also CYP3A4 and P-gp substrate

40
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DDIs VEL

  • Needs acidic environment for absorption

  • Interaction risk with acid-reducing agents

  • Inhibits P-gp, OATp1B1/3 (weak), BCRP (moderate)

  • Substrate of OATP1B1/3

  • Metabolized by CYP3A4, CYP2B6, CYP2C8

41
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DDIs for VOX

  • Substrate of OATP1B1/3

  • Metabolized by CYP3A4, CYP1A2, CYP2C8

42
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DDIs for G/P

  • Inhibit P-gp, BCRP, OATP1B1/3

  • Weakly inhibit CYP3A4, CYP1A2, UGT1A1

  • Broad potential for drug-drug interactions

43
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DAA Class of LDV

NS5A

44
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DAA Class of SOF

NS5B

45
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DAA Class of EBR

NS5A

46
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DAA Class of GZR

PI

47
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DAA Class of VEL

NS5A

48
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DAA Class of VOX

PI

49
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DAA Class of G/P

PI/NS5A