Paracetamol

Drug class

Analgesic & antipyretic

Pharmacology

p-aminophenol derivative that exhibits analgesic and antipyretic activity. it does not process significant anti-inflammatory activity.

metabolism

metabolised by the liver, excreted by the kidneys

Indications

mild to moderate pain, fever

Contraindications

allergy/ADR, pt less than 1 month

precautions hepatic dysfunction

Side effects

Nausea

presentation

500 mg tablet & 24 mg/mL liquid

onset

10-60 minutes

duration

4 hrs

plasma half -life

=2hr

Schedule

S2

Routes

PO

Special note: guardian administration?

Allowed if checked by QAS, documented as guardian dose.

Special note: dosing interval

4 hrs minimum

>16 years/adult dose

0.5-1g repeat every 4hr; max 4g in 24hrs

Why does paracetamol lack significant anti-inflammatory activity?

Because it is rapidly inactivated in peripheral inflamed tissue.

Does paracetamol have an effect on platelet aggregation?

No, it has no significant effect on platelet function.

What is the antidote for paracetamol overdose?

N-acetylcysteine (NAC) – restores glutathione.

Why is paracetamol often preferred over NSAIDs?

Safer for patients with GI disease, bleeding risk, asthma, or renal impairment.