aromatic groups have highly delocalized pi-electron orbitals above and below plane of ring
orbitals often interact with quaternary ammonium ions to form stable bonds that are important in enzyme-substrate interactions and receptor-agonist interactions
in aqueous media, the cation-pi interaction is comparable (potentially stronger than) ammonium-carboxylate salt bridges
aromatic side chains of phenylalanine, tryptophan, tyrosine, histidine are capable of binding to cationic species, such as quaternized amino groups, metal ions, neurotransmitters and pharmaceutical agents