PC 2 mod 2.2 lec 12

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Last updated 3:32 AM on 8/15/26
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11 Terms

1
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nature

FQ DID NOT COME FROM...

2
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no

does FQ have chiral centers?

3
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antibacterial

antibiotic

FQ is a _______ agent NOT _______

4
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inhibition of DNA synthase (DNA gyrase and topoisomerase)

MOA of FQ is by inhibition of ______

5
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ring on right with carboxyl group

what is the pharmacophore

<p>what is the pharmacophore</p>
6
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cell wall penetration and potency

the F on FQ serves for ______ and ______

7
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NO INTERFERES with binding

can the H between N and carboxyl be substituted

<p>can the H between N and carboxyl be substituted</p>
8
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- porin

- efflux pumps

- DNA gyrase and topo IV

- aminoglycoside acetyltransferase

mechanisms of fluoroquinolone resistance...

--> decrease ______

--> increased ______

--> target modification of _____ and _____

--> enzyme inactivation by _____

9
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enzyme-DNA cleavage complexes

FQ kill bacterial cells by increasing concentration of...

10
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group on N in ring

group next to F

which groups can be substituted for potency and spectrum of activity

<p>which groups can be substituted for potency and spectrum of activity</p>
11
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AAC (aminoglycosidase acetyltransferae)

______ enzyme decreases activity of aminoglycosides and FQ