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competitive inhibitors
increase Km, same Vmax
noncompetitive inhibitors
same Km, decrease Vmax
uncompetitive inhibitors
decrease Km, decrease Vmax
Glycolysis
location: cytosol
net products: 2 pyruvate, 2 ATP, 2 NADH
rate limiting step: PFK-1
activated by: AMP, F26BP
inhibited by: ATP, citrate
TCA
location: mitochondria
per 1 acetyl-CoA: 3 NADH, 1 FADH2, 1 GTP
rate limting: isocitrate dehydrogenase
ETC
complex I: NADH
complex II: FADH2
complex III: cytochrome c reduction
complex IV: O2 -» H2O
ATP synthase: complex V
gluconeogenesis
purpose: make glucose
location: liver
key enzymes: pyruvate carboxylase, PEP carboxykinase, F16Bphosphatase, G6phosphatase
glycogen
glycogenesis: build glycogen with glycogen synthase
glycogenolysis: break down glycogen with glycogen phosphorylase
pentose phosphate pathway
products: NADPH, ribose-5-phosphate
rate limiting step: G6PD