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Ingestion
The intake of food, typically through the mouth, marking the first step in digestion.
Digestion
The mechanical and chemical breakdown of food into forms usable by the body.
Mechanical digestion
The physical breakdown of food into smaller particles (e.g., chewing).
Chemical digestion
Hydrolysis reactions that break dietary macromolecules into monomers.
Absorption
The uptake of nutrient molecules into the epithelial cells of the digestive tract and then into the blood or lymph.
Compaction
Absorbing water and consolidating indigestible residue into feces.
Defecation
The elimination of feces from the digestive tract through the anus.
Alimentary canal
A muscular tube from mouth to anus including the oral cavity, pharynx, esophagus, stomach, small and large intestines.
Accessory organs
Organs that aid digestion but are not part of the digestive tract (e.g., teeth, tongue, salivary glands, liver, gallbladder, pancreas).
Peristalsis
Wave-like muscular contractions that move food through the digestive tract.
Enzyme
A biological catalyst that speeds up chemical digestion of macromolecules.
Saliva
A fluid secreted into the mouth containing enzymes (like amylase) and mucus to aid in digestion and lubrication.
Amylase
An enzyme in saliva that begins the chemical digestion of starch into maltose.
Gastric juice
Secretions from the stomach lining that include hydrochloric acid and pepsinogen.
Pepsin
An active enzyme in the stomach that digests proteins into shorter peptides.
Pepsin
An enzyme activated from pepsinogen that breaks down proteins in the stomach.
Chyme
A semi-fluid mixture of partially digested food and digestive secretions in the stomach.
Bile
A substance produced by the liver that emulsifies fats and aids in their digestion and absorption.
Bile
Contains bile salts, pigments, and cholesterol to emulsify fats for digestion.
Liver
An accessory organ that produces bile, processes nutrients, and detoxifies chemicals.
Gallbladder
Stores and concentrates bile before releasing it into the small intestine.
Pancreas
Secretes digestive enzymes and bicarbonate into the small intestine to neutralize stomach acid and aid digestion.
Villi
Fingerlike projections of the small intestinal mucosa that increase surface area for absorption.
Microvilli
Microscopic projections on the villi that further increase absorptive surface area.
Small intestine
Site of most chemical digestion and nutrient absorption.
Large intestine
Absorbs water and forms feces; includes the colon, rectum, and anal canal.
Mastication
The process of chewing food to begin mechanical digestion.
Swallowing (deglutition)
The reflexive act of moving food from the mouth to the esophagus.
Hydrochloric acid (HCl)
A component of gastric juice that activates pepsin and helps digest proteins.
Intrinsic factor
A glycoprotein secreted by the stomach needed for vitamin B12 absorption in the small intestine.
Intrinsic factor
Essential for vitamin B12 absorption in the ileum.
Lacteal
A lymphatic vessel in the villus of the small intestine that absorbs dietary lipids.
Segmentation
Mixing contractions in the small intestine that churn chyme and promote contact with digestive enzymes and absorptive cells.
Segmentation
Contractions in the small intestine that mix chyme with digestive enzymes.
Segmentation
Aids in nutrient absorption by increasing chyme contact with intestinal wall.
Enteric nervous system
A nervous network within the digestive tract wall that regulates digestive tract motility, secretion, and blood flow.
Enteric nervous system
A localized nervous network controlling digestion, secretion, and motility.
Ghrelin
Hunger hormone secreted by parietal cells; stimulates appetite and gastric motility.
Intrinsic factor
Glycoprotein secreted by parietal cells; essential for vitamin B12 absorption in the ileum.
Zymogen
Inactive enzyme precursor that must be activated to become functional; e.g., pepsinogen to pepsin.
Brush border enzymes
Enzymes embedded in microvilli of intestinal cells; responsible for final digestion steps of nutrients.
Contact digestion
Digestion that occurs when chyme contacts microvilli and brush border enzymes break down nutrients.
Segmentation
Contractions in small intestine that churn chyme and mix it with enzymes, aiding digestion.
Haustral contractions
Slow segmenting movements in the colon; mix contents and promote water absorption.
Mass movements
Strong peristaltic contractions in large intestine that move feces toward the rectum.
Defecation reflex
Involuntary reflex triggered by rectal stretching, leading to internal sphincter relaxation.
Defecation reflex
Initiated by stretch receptors in the rectal wall triggering muscle contractions.
Chylomicrons
Lipid-protein complexes formed in enterocytes; absorbed into lacteals and transported in lymph.
Micelles
Lipid transport structures formed by bile acids that carry lipids to the intestinal brush border.
Bilirubin
Pigment formed from hemoglobin breakdown; gives feces their brown color after conversion to urobilinogen.
CCK (cholecystokinin)
Hormone that stimulates gallbladder contraction and pancreatic enzyme secretion.
Secretin
Hormone that stimulates bicarbonate secretion from the pancreas and liver to neutralize stomach acid.
Urobilinogen
Product of bilirubin metabolism by gut bacteria; contributes to fecal and urinary coloration.
Lacteals
Lymphatic capillaries in intestinal villi that absorb dietary fats in the form of chylomicrons.
Pernicious anemia
Anemia caused by vitamin B12 deficiency due to lack of intrinsic factor.
Aminopeptidase
Brush border enzyme that removes amino acids from the amino end of peptides.
Dipeptidase
Brush border enzyme that splits dipeptides into free amino acids.
Nucleosidases
Brush border enzymes that break down nucleotides into nitrogenous bases and sugars.
Phosphatases
Brush border enzymes that remove phosphate groups from nucleotides during digestion.
Transferrin
Blood protein that binds and transports iron to tissues like bone marrow and liver.
Lecithin
Phospholipid that helps emulsify fats in the intestine with bile acids.
Gomphosis
A fibrous joint where a tooth is anchored into its socket by the periodontal ligament.
Periodontal ligament
Modified periosteum that anchors a tooth to the alveolar bone via collagen fibers.
Gingiva
Also known as the gum; covers the alveolar bone and surrounds the teeth.
Alveolus
The socket in the alveolar bone where a tooth is held.
Enamel
Hard, noncellular surface layer of a tooth that covers the crown.
Cementum
A bone-like material covering the root of the tooth, capable of regeneration.
Dentin
The yellowish tissue making up most of the tooth beneath the enamel and cementum.
Root canal
The tunnel within a tooth's root containing nerves and blood vessels.
Apical foramen
Opening at the end of a root canal that allows nerves and blood vessels to enter.
Occlusion
The contact between teeth when the mouth is closed.
Tight junctions
Connections between epithelial cells preventing leakage of gastric juice.
Mucous coat
Thick, alkaline mucus that protects the stomach lining from acid and enzymes.
Epithelial cell replacement
Rapid regeneration of stomach epithelium every 3 to 6 days.
Enterogastric reflex
Inhibitory reflex that slows gastric activity as chyme enters the small intestine.
Hepatic triad
A structure in the liver composed of a bile ductule, hepatic portal vein branch, and hepatic artery branch.
Bile canaliculi
Small ducts between hepatocytes that collect bile and transport it to bile ductules.
Lymphatic uptake
Absorption of chylomicrons by lacteals in the intestinal villi for transport via lymph.
Brush border
Microvilli-covered surface of intestinal epithelial cells where enzymes carry out final digestion.
Gastrectomy
Surgical removal of the stomach, requiring B12 supplementation due to loss of intrinsic factor.