HIT to lead 2

what can happen if there are more than 5 hydrogen bond donors and acceptors?

medium in the body is water so if there are too many, they will form strong hydrogen bonds and drug will not be able to partition into the membrane and desolve

why do liphophilic drugs have more interaction with CYP enzymes?

they are not very polar which makes them a target for the CYP enzymes to make them polar and eliminate them from the body

why do liphophilic drugs have more off target side effects?

hydrophobic interaction are less specific than polar so can bind to other targets

what is the aim in lead optimisation?

make the drug more safe and improve drug like properties

how can we minimize off target effects in drug design?

make the drug more portent so a small dose is given which will reduce the number of molecules in the body.

what is mechanism based toxicity?

when toxicity is linked to the drug binding to the right target