Cytokines

IL-1alpha

Always there, fever (hypothalamus), active phase response

IL-1beta

Inflammation, fever (hypothalamus), acute phase response

IL-3

growth of stem cells, differentiates myeloid (IL-3) and lymphoid (IL-3 and IL-7)

IL-4 and IL-13

Asthma and allergy response

IL-5

Eosinophil activation and chemotaxis

IL-6

Hypothalamus = fever

Liver = complement

IL-7

B and T cell development

IL-8

Chemotaxis and neutrophils

IL-10

Antagonistic, Treg = suppress immunity

IL-12

Increased lymphoid cell action during infection, activation and proliferation of T cells and natural killer (NK) cells

IL-17

Cytokine storm and neutrophils

IL-23

Maintains/supports IL-17, inflammation maintenance

Cytokine/s responsible for polarization of TH1 cells?

IL-12, IL-18, and IFN-gamma

Which cytokine/s increase selection affinity and expression on endothelium during extravasation?

Histamine, IL-1, and TNF

IL-2

Drives clonal expansion during lymphocyte responses

Which cytokine/s have both local and systemic effects during inflammation?

IL-1, IL-6, TNF-alpha

Which cytokine/s is used as a drug for chronic hepatitis B or C infection?

IFN-alpha

Which cytokine/s is responsible for TH2 polarization?

IL-2, IL-4

TGF-beta

Promotes Treg polarization

Which cytokine/s is used for treatment of neutropenia following chemotherapy?

G-CSF

Pleiotropic

IL-4 binds to CD marker on b cell causes IgE production, but if it binds to CD 4 cell it causes TH2 differentiation

Redundant

IL-2 and IL-4 can both stimulate B cell proliferation

Synergistic

TNF and IFN-gamma increase expression of class 1 MHC molecules on many cell types

Antagonistic

IFN-gamma causes macrophage activation while IL-10 causes inhibition of macrophage activation

IgE

Antibody for allergies