[VIROLOGY] Part 1 - Introduction

e. None

True about virus except:

a. Small infections units

b. Requires electron microscopy to be visialized

c. Obligate intracellular parasite

d. Cannot make energy or proteins independently of the host.

e. None

b. Virion

Mature viral particle which is the infective form.

a. Prion

b. Virion

c. Capsid

d. Enveloped

e. Plasmid

f. All

Viral component:

a. Nucleic acid genome

b. Capsid

c. Envelope

d. a and b

e. b and c

f. All

e. None

True about viral nucleic acid genome except:

a. Can be DNA or RNA

b. Single or double stranded

c. RNA positive sense mimics mRNA

d. RNA negative sense is converted first to mRNA and carry own polymerase

e. None

a. Positive sense

Viral RNA that mimics mRNA.

a. Positive sense

b. Negative sense

b. Negative sense

Viral RNA that is converted first to mRNA and carry own polymerase.

a. Positive sense

b. Negative sense

b. Capsid

Protective protein coat.

a. Nucleic acid genome

b. Capsid

c. Envelope

d. a and b

e. b and c

f. All

c. Capsomere

Subunit of capsid.

a. Viriod

b. Virion

c. Capsomere

d. Chromosome

d. a and b

Nucleic acid genome

Capsid

Nucleocapsid is composed of:

a. Nucleic acid genome

b. Capsid

c. Envelope

d. a and b

e. b and c

f. All

a. Icosahedral

Nucleocapsid that is 20 equilateral triangles.

a. Icosahedral

b. Helical

c. Complex

b. Helical

Nucleocapsid that is spiral shaped.

a. Icosahedral

b. Helical

c. Complex

c. Complex

Nucleocapsid of a bacteriophage.

a. Icosahedral

b. Helical

c. Complex

c. Envelope

Viral phospholipid bilayer which is obtained from host cell membrane as result from budding.

a. Nucleic acid genome

b. Capsid

c. Envelope

d. a and b

e. b and c

f. All

a. 456123

1- Attachment

2- Penetration

3- Uncoating

4- Biosynthesis

5- Assembly

6- Release

Viral multiplication cycle:

1- Biosynthesis

2- Assembly

3- Release

4- Attachment

5- Penetration

6- Uncoating

a. 456123

b. 465123

c. 456213

d. 465123

a. Attachment

Attachment to the target epithelial cell.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

b. Penetration

Engulfment of the virus.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

a. Naked virus

Penetration is through endocytosis.

a. Naked virus

b. Enveloped virus

b. Enveloped virus

Penetration is through fusion of envelope to host membrane.

a. Naked virus

b. Enveloped virus

c. Uncoating

Viral content release inside the cell.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

d. Biosynthesis

Viral RNA entry to the nucleus and replication through RNA polymerase.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

e. Assembly

Phage particles are assembled.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

f. Release

Viral particles release to the extracellular fluid.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

a. Naked virus

Release is through cell lysis.

a. Naked virus

b. Enveloped virus

b. Enveloped virus

Release is through budding.

a. Naked virus

b. Enveloped virus

a. Uncoating

Blocked by:

Amantadine

Rimantadine

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Packaging and assembly

e. Integration

f. Penetration

c. Nucleic acid synthesis

Blocked by:

NRTI

NNRTI

Nucleoside/Nucleotide analogues

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Packaging and assembly

e. Integration

f. Penetration

e. Integration - Integrase inhibitors

Blocked by "-gravirs".

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Packaging and assembly

e. Integration

f. Penetration

b. Viral protein synthesis - Protease inhibitors

Blocked by "-navirs".

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Packaging and assembly

e. Integration

f. Penetration

d. Viral release - Neuraminidase inhibitors

Blocked by "-mivirs".

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Viral release

e. Integration

f. Penetration

f. Penetration

Blocked by interferon-alfa.

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Viral release

e. Integration

f. Penetration

a. Viral attachment and entry

Blocked by:

Enfuvirtide

Docosanol

Maraviroc

Palivizumab

a. Viral attachment and entry

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Viral release

e. Integration

a. Viriod - RNA only

virion - NA + capsid

Smallest infective pathogen known.

a. Viriod

b. Virion

c. Capsid

d. Prion

a. Viriod

Circular ssRNA with composed of nucleic acid only and no protein coating that infects plants.

a. Viriod

b. Virion

c. Capsid

d. Prion

d. Prion

Smallest human pathogen composed of protein only.

a. Viriod

b. Virion

c. Capsid

d. Prion

d. Prion

Common misfolded brain protein that infects other proteins upon contact.

a. Viriod

b. Virion

c. Capsid

d. Prion

e. None

Prion clinical presentation is transmissible spongiform encephalopathy which is degenerative CNS disease resulting to sponge-like brain. This may include the following except:

a. Creutzfeldt-Jakob disease (CJD)

b. Mad cow disease

c. Kuru

d. Scrapie

e. None

f. All

DIN

Double-stranded

Icosahedral

Nucleus

Characteristic of DNA virus.

a. Double stranded

b. Icosahedral

c. Replication site is nucleus

d. a and b

e. b and c

f. All

a. Parvovirus

The only single stranded DNA virus.

a. Parvovirus

b. Poxviridae

c. Rhabdoviridae

d. Reoviridae

b. Poxviridae

The only complex DNA virus.

a. Parvovirus

b. Poxviridae

c. Rhabdoviridae

d. Reoviridae

b. Poxviridae

The only DNA virus replicated in the cytoplasm.

a. Parvovirus

b. Poxviridae

c. Rhabdoviridae

d. Reoviridae

a. I, II, III, IV, V, VI, VII

"Pardon PaPa As He Has Pox"

DNA Virus:

I. Parvoviridae

II. Papillomaviridae

III. Polyomaviridae

IV. Adenoviridae

V. Herpesviridae

VI. Hepadnaviridae

VII. Poxviridae

a. I, II, III, IV, V, VI, VII

b. I, II, III, IV

c. V, VI, VII

d. I, II, III

e. IV, V, VI, VII

PAPa mo nakahubad TT

• Parvoviridae

• Adenoviridae

• Papillomaviridae

• Polyomaviridae

Naked DNA Virus

• Herpesviridae

• Hepadnaviridae

• Poxviridae

Enveloped DNA Virus

e. None

HECS

Helical

Enveloped

Cytoplasm

Single-stranded

RNA virus general characteristics except:

a. Helical

b. Enveloped

c. Cytoplasmic replication

d. Single stranded

e. None

a. Rhabdoviridae

Only bullet shaped RNA virus.

a. Rhabdoviridae

b. Picornaviridae

c. Retroviridae

d. Reoviridae

d. Reoviridae

Only double stranded RNA virus.

a. Rhabdoviridae

b. Picornaviridae

c. Retroviridae

d. Reoviridae

Naghubad sa "PRC" - Naked RNA Virus:

• Picornavirus

• Reovirus

• Calicivirus

Only naked RNA virus

• Orthomyxovirus

• Retrovirus

Only RNA viruses replicate in the nucleus.

"PiCoTCaFlaRe"

• Picornavirus

• Coronavirus

• Togavirus

• Calicivirus

• Flavivirus

• Retrovirus

• Reovirus

Positive-sense RNA virus

"ParFABOR"

• Paramyxovirus

• Filovirus

• Arenavirus

• Bunyavirus

• Orthomyxovirus

• Rhabdovirus

Negative-sense RNA virus

FlaT sa PRC

Flavi-

Toga-

Picorna-

Reo-

Calici-

RNA viruses that are icosahedral in shape